ArticlePharmaceutics2024
Green Sol-Gel Synthesis of Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications.
Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Magnetic Cellulose Nanocrystal Composites: Synthesis, Properties, Applications, and Opportunities.Nanomaterials (Basel, Switzerland) · 2026Review
- Dual-Function Sol-Gel Antibacterial Materials with Biphasic Octenidine Release for Decontamination and Long-Term Protection.ACS omega · 2026Article
- Sol-Gel-Synthesized Metal Oxide Nanostructures: Advancements and Prospects for Spintronic Applications-A Comprehensive Review.Gels (Basel, Switzerland) · 2025Review
- Influence of the pH Synthesis of FePharmaceutics · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesThe unique properties of iron oxide nanoparticles have attracted significant interest within the biomedical community, particularly for magnetic hyperthermia applications. Various synthesis methods have been developed to optimize these nanoparticles.
methodsIn this study, we employed a powdered coconut water (PCW)-assisted sol-gel method to produce magnetite nanoparticles for the first time. A comprehensive analysis of the thermal (differential thermal analysis and thermogravimetry), structural (X-ray diffraction), morphological (scanning electron microscopy with energy dispersive spectroscopy), magnetic (vibrating sample magnetometer and hyperthermia), and biological (cytotoxicity essays) properties was conducted to assess their potential for magnetic hyperthermia.
resultsSamples heat-treated at 700 °C and 400 °C (washed powder) for 4 h under argon presented only magnetite in their composition. The micrometer-sized particles exhibited ferrimagnetic behavior, with saturation magnetization values of 37, 76, and 10 emu/g and specific absorption rates (SAR) of 27.1, 19.9, and 14.1 W/g, respectively, for treatments at 350 °C (48 h), 700 °C (4 h), and 400 °C (washed powder, 4 h) under an argon atmosphere. Biological tests showed no cytotoxicity below 10 mg/mL.
conclusionsThe findings highlight the potential of PCW-assisted synthesis as a sustainable and efficient strategy for producing pure magnetite, with powder washing preceding the heat treatment enabling the attainment of this phase at lower temperatures. Nevertheless, the micrometer-scale dimensions is observed in the morphological analysis limit their suitability for biomedical applications.
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