Evidence map›Paper›PMID 39771133›Full record

ArticleToxics2024

Associations Between Brominated Flame Retardant Exposure and Depression in Adults: A Cross-Sectional Study.

Yulan Cheng, Yue Fei, Zemin Xu, Ruiyao Huang, Yuling Jiang, Lihan Sun, Xuehai Wang, Shali Yu, Yonghua Luo, Xiaobo Mao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yulan ChengAffiliated Haimen Hospital of Xinglin College, Nantong University, Nantong 226019, China.
Yue FeiNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Zemin XuNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Ruiyao HuangDepartment of Clinical Medicine, Nantong University Xinglin College, Nantong 226000, China.
Yuling JiangNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Lihan SunSchool of Medicine, Nantong University, Nantong 226001, China.
Xuehai WangNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Shali YuNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.
Yonghua LuoNantong Fourth People's Hospital, Nantong 226019, China.
Xiaobo MaoAffiliated Haimen Hospital of Xinglin College, Nantong University, Nantong 226019, China.
Xinyuan ZhaoNantong Key Laboratory of Environmental Toxicology, Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China.ORCID 0000-0002-7317-8016

Funding

National Natural Science Foundation of China 82204085
6 · The paper itself

Abstract

backgroundBrominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population.

methodsTo analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used. In the final analysis, a total of 8138 adults aged 20 years and older were included. To investigate the potential relationship between BFRs and outcomes, we used binary logistic regression, restricted cubic spline (RCS), quantile-based g computation (QGC), and weighted quantile sum (WQS) regression.

resultsThe findings showed that serum BFR concentrations were associated with depressive symptoms over a broad spectrum. Binary logistic regression and RCS analysis showed that certain BFRs, particularly PBB153, were significantly and positively associated with the incidence of depression, even after adjustment for various confounders (

conclusionOur study identified new insights into the relationship between BFRs and depression, but sizable population-based cohort studies and toxicology mechanism studies will be needed to establish causality.

Indexed as

brominated flame retardantschemical mixture exposuredepressionNHANESquantile-based g computation

Identifiers

PMID39771133
PMCPMC11728815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.