Evidence map›Paper›PMID 39771108›Full record

ArticleToxics2024

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury.

Minghan Wang, Bin Wu, Kaiyang Tang, Xuexin Wang, Xinyan Liu, Yinan Duan, Jiayu Wang, Xiaoguang Wang, Yinyin Wang, Jun Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Minghan WangState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Bin WuDepartment of Surgery, The Second Affiliated Hospital of Jiaxing University, No. 397, Huangcheng North Road, Jiaxing 314000, China.
Kaiyang TangState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Xuexin WangMedical School of Chinese PLA, Chinese PLA General Hospital, Beijing 100853, China.
Xinyan LiuMedical School of Chinese PLA, Chinese PLA General Hospital, Beijing 100853, China.
Yinan DuanState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Jiayu WangState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Xiaoguang WangDepartment of Surgery, The Second Affiliated Hospital of Jiaxing University, No. 397, Huangcheng North Road, Jiaxing 314000, China.
Yinyin WangState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Jun LiJinfeng Laboratory, No. 313 Jinyue Road, High-Tech Zone, Chongqing 401329, China.
Chenxi CaoDepartment of Surgery, The Second Affiliated Hospital of Jiaxing University, No. 397, Huangcheng North Road, Jiaxing 314000, China.
Fangli RenState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.
Zhijie ChangState Key Laboratory of Membrane Biology, School of Medicine, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-1567-3227

Funding

the National Natural Science Foundation of China 81872249 and 82430087
6 · The paper itself

Abstract

BACKGROUND AND

aimsCell-cycle-related and expression elevated protein in tumor (CREPT, also named RPRD1B) is highly expressed in tumors and functions to promote tumorigenesis. However, the role of CREPT in the pathophysiology of acute liver injury is limited. Here, we demonstrate that CREPT plays an essential role during acute liver injury. APPROACH AND

resultsHepatocyte-specific CREPT knockout (

conclusionsThese results elucidate the role of CREPT in acute liver injury and provide hints for future research on how CREPT might function in hepatocyte renewal.

Indexed as

acute liver injuryCREPTNF-κB/Nrf2oxidative stress

Identifiers

PMID39771108
PMCPMC11728809

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.