Evidence map›Paper›PMID 39771055›Full record

ArticleToxics2024

Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.

Wenxiang Zeng, Shiqiao He, Ying Zhao, Minjian Jiang, Wenla Wang, Limeng Yang, Weibin Du, Wei Zhuang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenxiang ZengThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Shiqiao HeThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Ying ZhaoThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Minjian JiangThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Wenla WangThe Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Limeng YangJiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314500, China.
Weibin DuHangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311200, China.
Wei ZhuangHangzhou Xiaoshan Hospital of Traditional Chinese Medicine, Hangzhou 311200, China.

Funding

Hangzhou Biomedical and Health Industry Development Support Science and Technology Special Project 2023WJC236Special Project of Zhejiang University of Traditional Chinese Medicine Affiliated Hospital 2022FSYZY36
6 · The paper itself

Abstract

Microplastics (MPs) represent an emerging pollutant capable of entering the human body through the respiratory and digestive systems, thereby posing significant health risks. Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems, often presenting with polyarticular joint manifestations. Despite its relevance, there is currently limited research on the impact of MPs on lupus arthritis. This study aims to investigate the effects of MPs on joint inflammation in SLE.

Indexed as

cell pyroptosismicroplasticsMRL/lpr miceNF-κB signalingoxidative stresssynovitis

Identifiers

PMID39771055
PMCPMC11680006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.