Evidence map›Paper›PMID 39770986›Full record

ArticleNutrients2024

Gut Microbiota and Metabolites Mediate Health Benefits of Oat and Oat Bran Consumption in IBD Mice.

Wen Duan, Bisheng Zheng, Tong Li, Ruihai Liu

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wen DuanSchool of Food Sciences and Engineering, South China University of Technology, Guangzhou 510641, China.
Bisheng ZhengSchool of Food Sciences and Engineering, South China University of Technology, Guangzhou 510641, China.ORCID 0000-0003-1643-6493
Tong LiDepartment of Food Science, Cornell University, Ithaca, NY 14853, USA.
Ruihai LiuDepartment of Food Science, Cornell University, Ithaca, NY 14853, USA.

Funding

Innovative Leading Talents Project of Guangzhou Devel-opment Zone B17018
6 · The paper itself

Abstract

BACKGROUND/

objectivesInflammatory bowel disease (IBD) is a chronic condition influenced by a variety of factors, including genetics, the environment, and gut microbiota. The incidence of IBD is increasing globally. Previous studies have shown that interactions between diet and gut microbiota influence the pathogenesis and treatment of IBD. Proper dietary nutrition including oat and oat bran regulates chronic inflammation, which is essential for individual health, and is one of the essential factors in reducing inflammation in the body and keeping the immune system functioning properly, which plays a role in the prevention and treatment of diseases. However, the mechanism of action of whether oat and oat bran will alleviate chronic inflammation by modulating intestinal flora and metabolites remains unknown.

methodsTherefore, in this study, we have used a mouse model of dextran sulfate sodium (DSS) chronic colitis to analyze the composition of intestinal microbiota, short-chain fatty acid content, and the expression of the relevant genes.

resultsThe results showed that diets supplemented with oat and oat bran improved intestinal barrier parameters, decreased the levels of inflammatory factors, modulated the composition of intestinal microbiota, and increased the content of short-chain fatty acids.

conclusionsThis study provides strong evidence that dietary interventions with oats or oat bran may have potential applications in clinical nutrition and dietary interventions for chronic IBD.

Indexed as

AvenaDietary FiberDisease Models, AnimalFatty Acids, VolatileGastrointestinal MicrobiomeInflammatory Bowel DiseasesAnimalsColitisDextran SulfateDietIntestinal MucosaMaleMiceMice, Inbred C57BLDextran SulfateDietary FiberFatty Acids, Volatilebraninflammatory bowel diseasemicrobiotaoatswhole grain

Identifiers

PMID39770986
PMCPMC11676952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.