Evidence map›Paper›PMID 39770952›Full record

ArticleNutrients2024

Effects of Different Processing on miRNA and Protein in Small Extracellular Vesicles of Goat Dairy Products.

Yuqin Fan, Zhikang Li, Yanmei Hou, Chumin Tan, Sheng Xiong, Jinjing Zhong, Qiuling Xie

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuqin FanCollege of Life and Science Technology, Jinan University, Guangzhou 510632, China.ORCID 0009-0000-9965-794X
Zhikang LiCollege of Life and Science Technology, Jinan University, Guangzhou 510632, China.
Yanmei HouAusnutria Hyproca Nutrition Co., Ltd., Changsha 410200, China.
Chumin TanCollege of Life and Science Technology, Jinan University, Guangzhou 510632, China.
Sheng XiongGuangdong Province Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China.
Jinjing ZhongAusnutria Hyproca Nutrition Co., Ltd., Changsha 410200, China.
Qiuling XieGuangdong Province Key Laboratory of Bioengineering Medicine, Guangzhou 510632, China.ORCID 0000-0002-0225-0260

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSmall extracellular vesicles (sEVs) are nanosized vesicles with biological activities that exist in milk, playing functional roles in immunity, gut balance, and the nervous system. Currently, little is known about the impact of processing on milk sEVs.

methodsIn this study, sEVs were collected from raw goat milk (g-sEV), pasteurized goat milk (pg-sEV), and goat milk powder (

resultsThe characterization results revealed a decrease in diameter as the level of processing increased. High-throughput sequencing results showed that all three types of small extracellular vesicles were found to be rich in miRNA, and no significant differences were observed in the most abundant sEV species. Comparing with g-sEV, there were 3938 and 4645 differentially expressed miRNAs in pg-sEV and

conclusionsThese results indicate that extracellular vesicles have a protective effect on their cargo, while processing steps can have an impact on the size and quantity of the sEVs. Furthermore, processing can also lead to the loss of immune-related miRNA and proteins in sEVs.

Indexed as

Extracellular VesiclesGoatsMicroRNAsMilkAnimalsDairy ProductsPasteurizationProteomeProteomicsMicroRNAsProteomedairy processinggoat milkmiRNAproteomesmall extracellular vesicles

Identifiers

PMID39770952
PMCPMC11679568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.