Evidence map›Paper›PMID 39770872›Full record

ArticleMicroorganisms2024

Gram Negative Biofilms: Structural and Functional Responses to Destruction by Antibiotic-Loaded Mixed Polymeric Micelles.

Tsvetozara Damyanova, Rumena Stancheva, Milena N Leseva, Petya A Dimitrova, Tsvetelina Paunova-Krasteva, Dayana Borisova, Katya Kamenova, Petar D Petrov, Ralitsa Veleva, Ivelina Zhivkova and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Interference ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tsvetozara DamyanovaDepartment of Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.
Rumena StanchevaInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 103-A, 1113 Sofia, Bulgaria.
Milena N LesevaDepartment of Immunology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.ORCID 0000-0002-7370-2383
Petya A DimitrovaDepartment of Immunology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.ORCID 0000-0003-0920-3712
Tsvetelina Paunova-KrastevaDepartment of Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.ORCID 0000-0002-8376-8917
Dayana BorisovaDepartment of Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.
Katya KamenovaInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 103-A, 1113 Sofia, Bulgaria.ORCID 0000-0002-3303-427X
Petar D PetrovInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 103-A, 1113 Sofia, Bulgaria.ORCID 0000-0002-5777-2066
Ralitsa VelevaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.
Ivelina ZhivkovaNational Reference Laboratory "Control and Monitoring of Antimicrobial Resistance", Department of Clinical Microbiology, National Center of Infectious and Parasitic Disease, Yanko Sakuzov Blvd. 26, 1504 Sofia, Bulgaria.
Tanya Topouzova-HristovaFaculty of Biology, Sofia University "St. Kliment Ohridski", 8 Dragan Tsankov Blvd., 1164 Sofia, Bulgaria.ORCID 0000-0002-1575-0790
Emi HaladjovaInstitute of Polymers, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 103-A, 1113 Sofia, Bulgaria.ORCID 0000-0003-2388-3873
Stoyanka StoitsovaDepartment of Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.ORCID 0000-0002-2378-3883

Funding

National Science Fund of Bulgaria KP-06-H41/8
6 · The paper itself

Abstract

Biofilms are a well-known multifactorial virulence factor with a pivotal role in chronic bacterial infections. Their pathogenicity is determined by the combination of strain-specific mechanisms of virulence and the biofilm extracellular matrix (ECM) protecting the bacteria from the host immune defense and the action of antibacterials. The successful antibiofilm agents should combine antibacterial activity and good biocompatibility with the capacity to penetrate through the ECM. The objective of the study is the elaboration of biofilm-ECM-destructive drug delivery systems: mixed polymeric micelles (MPMs) based on a cationic poly(2-(dimethylamino)ethyl methacrylate)-b-poly(ε-caprolactone)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA

Indexed as

biocompatibilitybiofilm destructioncationic polymersdrug deliveryextracellular vesiclesex vivo skin modelmixed polymer micellesnanotubules

Identifiers

PMID39770872
PMCPMC11728461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.