Evidence map›Paper›PMID 39770658›Full record

ArticleMicroorganisms2024

Modulation of

Samuele Sabbatini, Linda Zatini, Eleonora Narducci, Lucrezia Rosati, Andrea Ardizzoni, Antonella Mencacci, Mario Rende, Eva Pericolini, Francesco Galli, Desirée Bartolini and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuele SabbatiniDepartment of Medicine and Surgery, Medical Microbiology Section, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0001-8334-8325
Linda ZatiniDepartment of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.
Eleonora NarducciDepartment of Medicine and Surgery, Medical Microbiology Section, University of Perugia, 06123 Perugia, Italy.
Lucrezia RosatiDepartment of Medicine and Surgery, Pharmacology Division, University of Perugia, 06132 Perugia, Italy.
Andrea ArdizzoniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-9845-7399
Antonella MencacciDepartment of Medicine and Surgery, Medical Microbiology Section, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0001-9221-6172
Mario RendeDepartment of Medicine and Surgery, Section of Human, Clinical and Forensic Anatomy, University of Perugia, 60132 Perugia, Italy.
Eva PericoliniDepartment of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0002-5299-8197
Francesco GalliDepartment of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0003-3626-051X
Desirée BartoliniDepartment of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy.ORCID 0000-0003-3849-757X
Claudia MonariDepartment of Medicine and Surgery, Medical Microbiology Section, University of Perugia, 06123 Perugia, Italy.ORCID 0000-0002-5027-9367

Funding

European Union Next Generation EU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS0000041-VITALITY (CUPJ97G22000170005)University of Perugia Departmental funds for basic re-380 search-2019 and 2021 Monari
6 · The paper itself

Abstract

Vulvovaginal candidiasis (VVC) is a prevalent women's infection characterized by excessive inflammation and damage of the vaginal epithelium that, in its recurrent form (RVVC), causes more than three symptomatic episodes per year, impacting nearly 8% of women globally. Current antifungal treatments alleviate symptoms but often fail to restore the inflammatory homeostasis of mucosal tissue and prevent recurrences. α-Tocopherol (α-TOH) and garcinoic acid (GA), a vitamin E metabolite, with immunomodulatory properties, were investigated for the first time in vaginal epithelial cells exposed to

Indexed as

C. albicansgarcinoic acidvaginal cellsVVC-RVVC

Identifiers

PMID39770658
PMCPMC11678841

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.