Evidence map›Paper›PMID 39770522›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Antibacterial and Anti-Influenza Activities of

Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni and 3 more

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Current issues in molecular biology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michele PellegrinoDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.
Paola ChecconiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0001-7518-5730
Jessica CeramellaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0002-1386-3601
Carla PreziosoDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0002-8377-0742
Dolores LimongiDepartment for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.
Maria MarraDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.
Annaluisa MaricondaDepartment of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-9763-838X
Alessia CatalanoDepartment of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70126 Bari, Italy.ORCID 0000-0002-7420-4706
Marta De AngelisDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-1916-6508
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4427-4823
Maria Stefania SinicropiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-2435-8931
Pasquale LongoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.ORCID 0000-0002-7685-1093
Stefano AquaroDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Piazzale Salvatore Tommasi 1, Blocco 11, Coppito, 67010 L'Aquila, Italy.ORCID 0000-0002-8417-2103

Funding

Italian Ministry of Instruction, University and Research-MIUR PRIN 2022HARH5W, PRIN 2020KSY3KL_005, PRIN 2022FRE3RH, PRIN -2022 PNRR Prot. P2022WRRNT
6 · The paper itself

Abstract

BACKGROUND/

objectivesInfectious diseases represent a serious threat due to rising antimicrobial resistance, particularly among multidrug-resistant bacteria and influenza viruses. Metal-based complexes, such as

methodsEight NHC-gold complexes were synthesized and tested for antibacterial activity against

resultsComplexes 3, 4, and 6 showed significant antibacterial activity at concentrations of 10-20 µg/mL. Additionally, these complexes significantly reduced viral load, with complexes 3 and 4 markedly inhibiting replication.

conclusionsThese findings support the potential use of NHC-gold complexes in combined antimicrobial and antiviral therapies, representing an attractive option for fighting resistant infections.

Indexed as

antimicrobialsdrug resistanceinfluenza virusmetal-based therapeuticsN-heterocyclic carbene–gold complexes

Identifiers

PMID39770522
PMCPMC11677531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.