Evidence map›Paper›PMID 39770450›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Autism-Linked Mutations in α

Sabrin Haddad, Manuel Hessenberger, Cornelia Ablinger, Clarissa Eibl, Ruslan Stanika, Marta Campiglio, Gerald J Obermair

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabrin HaddadDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.ORCID 0009-0008-2049-9976
Manuel HessenbergerDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Cornelia AblingerDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Clarissa EiblDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.ORCID 0000-0001-8248-5133
Ruslan StanikaDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Marta CampiglioInstitute of Physiology, Medical University Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9629-2073
Gerald J ObermairDivision of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.ORCID 0000-0003-0005-8563

Funding

FWF Austrian Science Fund DOC30Gesellschaft für Forschungsförderung Niederösterreich FTI22-D-013Gesellschaft für Forschungsförderung Niederösterreich LSC19-017
6 · The paper itself

Abstract

backgroundα

methodsElectrophysiological recordings in transfected tsA201 cells were used to study specific channel-dependent functions of mutated α

resultsHomologous expression of both mutated α

conclusionsOur data provide evidence that the pathophysiological mechanisms of ASD-causing mutations of α

Indexed as

autism spectrum disorderauxiliary subunitcalcium currentcultured hippocampal neuronselectrophysiologytrans-synaptic functionvoltage-gated calcium channels

Identifiers

PMID39770450
PMCPMC11677996

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.