Evidence map›Paper›PMID 39770444›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Pharmacokinetics of Oral Cannabinoid Δ8-Tetrahydrocannabivarin and Its Main Metabolites in Healthy Participants.

Cristina Sempio, Jorge Campos-Palomino, Jelena Klawitter, Erica N Peters, Laura MacNair, Mehdi Haghdoost, Marcel O Bonn-Miller, Amy Harrison, Shanna Babalonis, Uwe Christians and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Side-Chain Homologs of ΔMolecular neurobiology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina SempioDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8095-612X
Jorge Campos-PalominoDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Jelena KlawitterDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1893-6141
Erica N PetersCanopy Growth Corporation, One Hershey Drive, Smiths Falls, ON K7A 0A8, Canada.ORCID 0000-0002-5563-9819
Laura MacNairCanopy Growth Corporation, One Hershey Drive, Smiths Falls, ON K7A 0A8, Canada.
Mehdi HaghdoostCanopy Growth Corporation, One Hershey Drive, Smiths Falls, ON K7A 0A8, Canada.
Marcel O Bonn-MillerCanopy Growth Corporation, One Hershey Drive, Smiths Falls, ON K7A 0A8, Canada.ORCID 0000-0001-5088-5386
Amy HarrisonCanopy Growth Corporation, One Hershey Drive, Smiths Falls, ON K7A 0A8, Canada.
Shanna BabalonisDepartment of Behavioral Science, University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-1450-2621
Uwe ChristiansDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-7297-147X
Jost KlawitterDepartment of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-6413-4820

Funding

Canopy Growth Corporation N/A
6 · The paper itself

Abstract

backgroundTetrahydrocannabivarin (THCV) is a phytocannabinoid commonly found in cannabis with potential pharmacological properties; however, its post-acute pharmacokinetics (PK) in humans have not been studied yet. THCV has two isomers, Δ9- and Δ8-THCV, which seem to have different pharmacological properties. We investigated the PK of the Δ8-THCV isomer after oral administration as part of a two-phase, dose-ranging, placebo-controlled trial in healthy participants.

methodsParticipants (

resultsAfter oral administration, 11-nor-9-carboxy-Δ8-THCV (Δ8-THCV-COOH) was the main metabolite detected. The median time-to-maximum concentration (t

conclusionsFor the first time, we report the pharmacokinetics of Δ8-THCV and its major metabolites after oral administration in humans. Δ8-THCV AUC

Indexed as

cannabinoidsmetabolitespharmacokineticTHCV

Identifiers

PMID39770444
PMCPMC11676667

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.