Evidence map›Paper›PMID 39770374›Full record

ArticlePathogens (Basel, Switzerland)2024

Pathology and VP2-Based Characterization of Infectious Bursal Disease Virus Associated with an Outbreak in Layer Chickens in Ghana.

Ben Enyetornye, Henry A Abugri, Ama K Kusi-Appiah, Grazieli Maboni, Theophilus Odoom, Nicole L Gottdenker, Binu T Velayudhan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ben EnyetornyeAthens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0003-3486-7211
Henry A AbugriSchool of Veterinary Medicine, University of Ghana, Legon, Accra P.O. Box LG139, Ghana.ORCID 0009-0001-7230-3946
Ama K Kusi-AppiahSchool of Veterinary Medicine, University of Ghana, Legon, Accra P.O. Box LG139, Ghana.ORCID 0009-0006-1765-9735
Grazieli MaboniAthens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Theophilus OdoomAccra Veterinary Laboratory, Veterinary Services Directorate, Accra P.O. Box GA184, Ghana.ORCID 0000-0002-7092-7237
Nicole L GottdenkerDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-3499-2410
Binu T VelayudhanAthens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0002-0500-1841

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious bursal disease (IBD) continues to threaten poultry production globally, with highly virulent strains circulating in many parts of Africa. In this study, molecular characterization was performed on a circulating infectious bursal disease virus (IBDV) strain from an outbreak in a layer flock in Ghana. Layer chicks presented for necropsy had markedly enlarged and hemorrhagic bursae of Fabricius, with necrotic foci and catarrhal exudate on the serosal surface. Histopathology of the bursa of Fabricius revealed scattered to effacing hemorrhages on the plicae, extensive necrosis with expansion of the stroma between the follicles, and depletion of lymphocytes within the interfollicular epithelium. Reverse transcription polymerase chain reaction (RT-PCR) and subsequent sequencing of the VP2 gene showed the presence of IBDV in formalin-fixed paraffin-embedded tissues. A phylogenetic analysis compared 62 other IBDV sequences from different parts of the world and placed the Ghanaian IBDV in genogroup 3 (vvIBDV), closely related to IBDV from Nigeria. In comparison to reference vvIBDV, there were amino acid substitutions at positions 252, 254, and 300. To the best of our knowledge, this is the first report in which an IBDV from a disease outbreak in Ghana has been sequenced and compared with other IBDVs in a phylogenetic analysis.

Indexed as

Birnaviridae InfectionsChickensDisease OutbreaksInfectious bursal disease virusPhylogenyPoultry DiseasesViral Structural ProteinsAnimalsBursa of FabriciusGhanaViral Structural ProteinsVP2 protein, infectious bursal disease viruschickensGhanainfectious bursal diseasepathologyphylogenetic analysis

Identifiers

PMID39770374
PMCPMC11677493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.