Evidence map›Paper›PMID 39770108›Full record

ArticleMolecules (Basel, Switzerland)2024

Regioselective Nucleophilic Aromatic Substitution: Theoretical and Experimental Insights into 4-Aminoquinazoline Synthesis as a Privileged Structure in Medicinal Chemistry.

Maria Letícia de Castro Barbosa, Pedro de Sena Murteira Pinheiro, Raissa Alves da Conceição, José Ricardo Pires, Lucas Silva Franco, Carlos Mauricio R Sant'Anna, Eliezer J Barreiro, Lídia Moreira Lima

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Letícia de Castro BarbosaFaculty of Pharmacy, Department of Pharmaceutical Sciences, Federal University of Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil.ORCID 0000-0002-1764-8650
Pedro de Sena Murteira PinheiroLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0003-4148-4243
Raissa Alves da ConceiçãoFaculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-8264-7673
José Ricardo PiresInstitute of Medical Biochemistry Leopoldo de Meis (IBqM), Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0001-6610-8530
Lucas Silva FrancoLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-0121-3011
Carlos Mauricio R Sant'AnnaLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0003-1989-5038
Eliezer J BarreiroLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0003-1759-0038
Lídia Moreira LimaLaboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil.ORCID 0000-0002-8625-6351

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.000090/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.718/2024; SEI-260003/006052/2024National Council for Scientific and Technological Development 465.249/2014-0National Institute of Science and Technology of Drugs and Medicines CNPq 465.249/2014-0
6 · The paper itself

Abstract

The 4-aminoquinazoline scaffold is a privileged structure in medicinal chemistry. Regioselective nucleophilic aromatic substitution (S

Indexed as

Chemistry, PharmaceuticalQuinazolinesDensity Functional TheoryMagnetic Resonance SpectroscopyModels, MolecularMolecular StructureStereoisomerism4-aminoquinazolineQuinazolinesaminoquinazolinedensity functional calculationsmedicinal chemistryNMR spectroscopynucleophilic substitutionregioselectivity

Identifiers

PMID39770108
PMCPMC11678402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.