Evidence map›Paper›PMID 39770084›Full record

ArticleMolecules (Basel, Switzerland)2024

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents.

Alba Rodriguez-Paniagua, Cinzia Tesauro, Birgitta R Knudsen, Maria Fuertes, Concepción Alonso

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alba Rodriguez-PaniaguaDepartamento de Química Orgánica I, Facultad de Farmacia and Centro de Investigación Lascaray (Lascaray Research Center), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.ORCID 0009-0004-8912-6386
Cinzia TesauroDepartment of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus, Denmark.
Birgitta R KnudsenDepartment of Molecular Biology and Genetics and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus, Denmark.
Maria FuertesDepartamento de Química Orgánica I, Facultad de Farmacia and Centro de Investigación Lascaray (Lascaray Research Center), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Concepción AlonsoDepartamento de Química Orgánica I, Facultad de Farmacia and Centro de Investigación Lascaray (Lascaray Research Center), Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0003-0866-3493

Funding

Basque Government IT1701-22Ministerio de Ciencia, Innovación y Universidades PID2021-122558OB-I00
6 · The paper itself

Abstract

The synthesis of phosphorous indenoquinolines and their biological evaluation as topoisomerase 1 (TOP1) inhibitors and antiproliferative agents were performed. First, the preparation of new hybrid 5

Indexed as

Antineoplastic AgentsCell ProliferationDNA Topoisomerases, Type IPhosphinesQuinolinesTopoisomerase I InhibitorsCell Line, TumorDrug Screening Assays, AntitumorHumansIndenesMolecular StructureOxidesStructure-Activity RelationshipAntineoplastic AgentsDNA Topoisomerases, Type IIndenesOxidesphosphinePhosphinesQuinolinesTOP1 protein, humanTopoisomerase I Inhibitorsantiproliferative agentsenzyme inhibitionindenoquinolinesphosphine oxidetopoisomerase I

Identifiers

PMID39770084
PMCPMC11678328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.