Evidence map›Paper›PMID 39770081›Full record

ArticleMolecules (Basel, Switzerland)2024

Analysis Profiling of 48 Endogenous Amino Acids and Related Compounds in Human Plasma Using Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry.

Xiongwei Yin, Irene Baldoni, Erwin Adams, Ann Van Schepdael

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiongwei YinDepartment of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven, 3000 Leuven, Belgium.
Irene BaldoniDepartment of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven, 3000 Leuven, Belgium.
Erwin AdamsDepartment of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4545-2989
Ann Van SchepdaelDepartment of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-9583-984X

Funding

Chinese Scholarship Council 202108510041
6 · The paper itself

Abstract

Analyzing and detecting endogenous amino acids in blood is of crucial importance for the diagnosis of medical conditions and scientific research. Considering the lack of UV chromophores in most of these analytes and the presence of several interfering substances in plasma, the quantification of quite a few amino acids and related compounds presents certain technical challenges. As a blank plasma matrix lacking these endogenous substances does not exist, the surrogate matrix method is used, as well as isotopic internal standards for calibration, to ensure the accuracy and reliability of the study. Method validation was conducted for 48 target analytes, giving the following results: linearity (R

Indexed as

Amino AcidsHydrophobic and Hydrophilic InteractionsTandem Mass SpectrometryChromatography, LiquidHumansReproducibility of ResultsAmino Acidsamino acidsHILIC-MS/MSnon-derivatizationplasmaquantitativesurrogate matrix method

Identifiers

PMID39770081
PMCPMC11678698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.