Iridium-Catalyzed Highly Selective 1,4-Reduction of α,β-Unsaturated Carbonyl Compounds.

Youwei Chen, Jide Li, Jiaxi Xu, Zhanhui Yang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Youwei ChenDepartment of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.

Jide LiDepartment of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.

Jiaxi XuDepartment of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0002-9039-4933

Zhanhui YangDepartment of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0001-7050-8780

Funding

National Key Research and Development Program of China 2022YFF0709803

6 · The paper itself

Abstract

In this study, an iridium-catalyzed selective 1,4-reduction of α,β-unsaturated carbonyl compounds is realized, with water as a solvent and formic acid as a hydride donor. The new efficient iridium catalyst features a 2-(4,5-dihydroimidazol-2-yl)quinoline ligand. The chemoselectivity and catalyst efficiency are highly dependent on the electronic and steric properties of the substrates. For α,β-unsaturated amides, acids, and esters, only the electron-deficient C=C bonds are reduced (1,4-reduction), and the other functional groups are left intact. The

Indexed as

alkenesformic acidiridium catalysistransfer hydrogenationwater solvent

Identifiers

PMID39770002

DOI10.3390/molecules29245912

PMCPMC11678408

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