Evidence map›Paper›PMID 39769993›Full record

ReviewMolecules (Basel, Switzerland)2024

Engineered Strategies for Lipid Droplets-Targeted AIEgens Based on Tetraphenylethene.

Fei Zhang, Yao Zhang, Zhuoxia Li, Xiaoxiao Wu, Dong Wang, Youling He, Hong Cheng, Baolei Fan, Dan Zhu, Min Li and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fei ZhangHubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437000, China.
Yao ZhangSchool of Health Service and Management, Shanxi University of Chinese Medicine, 121 University Street, Jinzhong 030619, China.
Zhuoxia LiDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xiaoxiao WuXianning Public Inspection and Testing Center, Xianning 437000, China.
Dong WangCenter for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0001-5137-0771
Youling HeCenter for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Hong ChengHubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437000, China.
Baolei FanHubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437000, China.
Dan ZhuHubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437000, China.ORCID 0009-0006-8630-193X
Min LiDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0002-0047-2804
Ben Zhong TangSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen 518172, China.

Funding

National Natural Science Foundation of China 81874208National Natural Science Foundation of China 82172754Scientific Research Fund for the Doctoral Young Scholars, SXTCM 2023BK27Shanxi Traditional Chinese Medicine Administration Project 2023ZYYB2034the Doctoral Research Initiation Project of Hubei University of Science and Technology BK202431the Doctoral Research Initiation Project of Hubei University of Science and Technology BK202435
6 · The paper itself

Abstract

Lipid droplets (LDs), once regarded as inert fat particles, have been ignored by scientific researchers for a long time. Now, studies have shown that LDs are dynamic organelles used to store neutral lipids in cells and maintain cell stability. The abnormality of intracellular LDs usually causes metabolic disorders in the body, such as obesity, atherosclerosis, diabetes, and cancer, so the LDs have attracted wide attention. The traditional small molecules used for LDs recognition seriously affect the imaging effect due to their poor photo-stability, low signal-to-noise ratios, and aggregation-induced quenching (ACQ). In contrast to ACQ, aggregation-induced emission (AIE) materials, with structural modifiability, can make up for the aforementioned deficiencies in the field of fluorescence imaging and have attracted much attention. In this review, the importance of LDs in vivo, the design principles for LDs recognition, and the recent research progress of AIE compounds with tetraphenylethene (TPE) structure in LDs targets are reviewed. We expect this review to further provide researchers with feasible methods and protocols for expanding LDs identification, imaging, and other applications.

Indexed as

Lipid DropletsAnimalsFluorescent DyesHumansOptical ImagingStilbenesFluorescent DyesStilbenestetraphenylethyleneaggregation-induced emissionfluorescence imaginglipid dropletstetraphenylethene

Identifiers

PMID39769993
PMCPMC11676262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.