Evidence map›Paper›PMID 39769951›Full record

ArticleMolecules (Basel, Switzerland)2024

5-Substituted Flavones-Another Class of Potent Triplex DNA-Specific Ligands as Antigene Enhancers.

Landy Gu, Nghia Tran, Vanessa M Rangel, Mandeep Singh, Krege M Christison, Geoff P Lin-Cereghino, Liang Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Landy GuDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
Nghia TranDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
Vanessa M RangelDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
Mandeep SinghDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.ORCID 0000-0002-3930-9588
Krege M ChristisonDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
Geoff P Lin-CereghinoDepartment of Biological Sciences, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.
Liang XueDepartment of Chemistry, University of the Pacific, 3601 Pacific Avenue, Stockton, CA 95211, USA.

Funding

Development of flavone- and flavonoid-based DNA triplex specific binding ligands as antigene enhancersR15GM148914 · NIGMS · UNIVERSITY OF THE PACIFIC-STOCKTON · PI XUE, LIANG · 2022 to 2023
$346k
NIGMS NIH HHS R15 GM148914NIH HHS 1R15GM148914-01
6 · The paper itself

Abstract

In the field of drug development, the quest for novel compounds that bind to DNA with high affinity and specificity never ends. In the present work, we report the newest development in this field, namely, triplex DNA-specific binding ligands based on the 5-substituted flavone scaffold in our lab. Biophysical studies showed that the newly synthesized flavone derivatives (depending on the side chains) bind to triplex DNA with binding affinities better than or similar to 5-substituted 3,3',4',7-tetramethoxyflavonoids. These compounds selectively stabilize triplex DNA while having little effect on duplex DNA, as verified by various biophysical methods. A detailed structural analysis suggested that the binding of these compounds to triplex DNA depends on the type of amino groups in the side chains and the length of the side chains. Viscosity studies suggested that these ligands bind to triplex DNA via intercalation. A representative ligand, compound

Indexed as

DNAFlavonesAntineoplastic AgentsCell Line, TumorHumansLigandsMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsDNAFlavonesLigandstriplex DNAflavonesligand-mediated triplex formationmicrocalorimetrytriplex-specific ligands

Identifiers

PMID39769951
PMCPMC11678237

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.