Synthesis of Oxazoles Containing CF

Juan-Juan Gao, Long-Hui Wu, Shu-Qin Yu, Xue Zhu, Yu Zeng, Kai Yang, Zhao-Yang Wang

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Juan-Juan GaoJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Long-Hui WuJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Shu-Qin YuJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Xue ZhuJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Yu ZengSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, China.

Kai YangJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, College of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Zhao-Yang WangSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, China.ORCID 0000-0002-2391-5938

Funding

Guangdong Basic and Applied Basic Research Foundation 2021A1515012342Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province 202410413011Natural Science Foundation of Jiangxi Province 20224BAB203010Science and Technology Projects of Ganzhou 2023CYZ17866

6 · The paper itself

Abstract

Oxazoles are important five-membered heterocycles that contain both nitrogen and oxygen atoms. Due to their wide range of biological activities, many oxazoles demonstrate potential for extensive application in various fields, including medicinal chemistry. Trifluoromethyl carbinol, an important pharmacophore, contains both trifluoromethyl and hydroxyl groups and is common in molecules with important biological activities. Constructing oxazoles that contain a trifluoromethyl carbinol unit is undoubtedly important and valuable for expanding the chemical space in drug discovery. In this study, a simple and efficient method was developed for the synthesis of oxazoles containing a CF

Indexed as

cycloisomerizationhydroxyalkylationN-propargylamideoxazoletandem reactiontrifluoromethyl carbinol unit

Identifiers

PMID39769937

DOI10.3390/molecules29245848

PMCPMC11728596

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.