Evidence map›Paper›PMID 39769502›Full record

ArticleInternational journal of molecular sciences2024

Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population.

Alena Kalyakulina, Igor Yusipov, Elena Kondakova, Tatiana Sivtseva, Raisa Zakharova, Sergey Semenov, Tatiana Klimova, Elena Ammosova, Arseniy Trukhanov, Claudio Franceschi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alena KalyakulinaArtificial Intelligence Research Center, Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.ORCID 0000-0001-9277-502X
Igor YusipovArtificial Intelligence Research Center, Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.ORCID 0000-0002-0540-9281
Elena KondakovaArtificial Intelligence Research Center, Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.ORCID 0000-0002-6123-8181
Tatiana SivtsevaResearch Center of the Medical Institute, M.K. Ammosov North-Eastern Federal University, 677013 Yakutsk, Russia.ORCID 0000-0002-1501-7433
Raisa ZakharovaResearch Center of the Medical Institute, M.K. Ammosov North-Eastern Federal University, 677013 Yakutsk, Russia.ORCID 0000-0002-1395-8256
Sergey SemenovResearch Center of the Medical Institute, M.K. Ammosov North-Eastern Federal University, 677013 Yakutsk, Russia.ORCID 0000-0001-8099-2270
Tatiana KlimovaResearch Center of the Medical Institute, M.K. Ammosov North-Eastern Federal University, 677013 Yakutsk, Russia.
Elena AmmosovaResearch Center of the Medical Institute, M.K. Ammosov North-Eastern Federal University, 677013 Yakutsk, Russia.
Arseniy TrukhanovMriya Life Institute, National Academy of Active Longevity, 124489 Moscow, Russia.
Claudio FranceschiInstitute of Biogerontology, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.ORCID 0000-0001-9841-6386
Mikhail IvanchenkoArtificial Intelligence Research Center, Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, 603022 Nizhny Novgorod, Russia.

Funding

Analytical Center for the Government of the Russian Federation agreement identifier 000000D730324P540002, grant No 70-2023-001320 dated 27.12.2023
6 · The paper itself

Abstract

Yakutia is one of the coldest permanently inhabited regions in the world, characterized by a subarctic climate with average January temperatures near -40 °C and the minimum below -60 °C. Recently, we demonstrated accelerated epigenetic aging of the Yakutian population in comparison to their Central Russian counterparts, residing in a considerably milder climate. In this paper, we analyzed these cohorts from the inflammaging perspective and addressed two hypotheses: a mismatch in the immunological profiles and accelerated inflammatory aging in Yakuts. We found that the levels of 17 cytokines displayed statistically significant differences in the mean values between the groups (with minimal

Indexed as

BiomarkersCold ClimateCytokinesInflammationAdultAgedAgingFemaleHumansMaleMiddle AgedSiberiaBiomarkersCytokinesclimatecold environmentdeep neural networkexplainable artificial intelligenceinflammatory profileYakutia

Identifiers

PMID39769502
PMCPMC11679676

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.