Evidence map›Paper›PMID 39769453›Full record

ArticleInternational journal of molecular sciences2024

Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Aging Apolipoprotein E4 Mice Alters Their Brains' Inflammatory Profiles.

Thao N Huynh, Emma N Fikse, Adrianna L De La Torre, Matthew C Havrda, Catherine C Y Chang, Ta Yuan Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Neuroinflammation: Advancements in Pathophysiology and Therapies.International journal of molecular sciences · 2025
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Thao N HuynhDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Emma N FikseDepartment of Molecular and System Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Adrianna L De La TorreDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Matthew C HavrdaDepartment of Molecular and System Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Catherine C Y ChangDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID 0000-0002-2187-8299
Ta Yuan ChangDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Nlrp3 in the development of Alzheimer's pathology in aging mice exposed to chlorpyrifosR01ES024745 · NIEHS · UNIVERSITY OF NEW ENGLAND · PI Matthew Charles Havrda · 2015 to 2026
$4.1M
Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storageR01AG063544 · NIA · DARTMOUTH COLLEGE · PI CHANG, TA YUAN · 2018 to 2021
$2.3M
Mechanisms and indicators of inflammasome signaling in Parkinson’s diseaseR01ES033462 · NIEHS · DARTMOUTH COLLEGE · PI HAVRDA, MATTHEW CHARLES · 2021 to 2023
$1.9M
NCI NIH HHS P30 CA023108NIA NIH HHS R01 AG063544NIEHS NIH HHS R01 ES024745NIEHS NIH HHS R01 ES033462NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Aging and apolipoprotein E4 (

Indexed as

Apolipoprotein E4BrainToll-Like Receptor 4Acetyl-CoA C-AcetyltransferaseAgingAnimalsATP Binding Cassette Transporter 1CholesterolCholesterol EstersFemaleInflammationMiceMice, Inbred C57BLMicrogliaNeuroinflammatory DiseasesSterol O-AcyltransferaseAcat1 protein, mouseAcetyl-CoA C-AcetyltransferaseApolipoprotein E4ATP Binding Cassette Transporter 1CholesterolCholesterol EstersSterol O-Acyltransferasesterol O-acyltransferase 1Tlr4 protein, mouseToll-Like Receptor 4ACAT inhibitoracyl-CoA:cholesterol acyltransferaseAlzheimer’s diseaseapolipoprotein E4 (APOE4)ATP binding cassette subfamily A member 1cholesterolcholesteryl estersDSPE-PEG2000F12511interleukin-1 betalate-onset Alzheimer’s diseaselipid raftsLOADmicrogliaNFκBphosphatidylcholinesterol O-acyltransferase 1TLR4

Identifiers

PMID39769453
PMCPMC11727783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.