Evidence map›Paper›PMID 39769441›Full record

ArticleInternational journal of molecular sciences2024

Dysregulated miRNA Expression and Androgen Receptor Loss in Racially Distinct Triple-Negative Breast Cancer.

Shristi Bhattarai, Bruna M Sugita, Emanuelle Nunes-Souza, Aline S Fonseca, Darshan Shimoga Chandrashekar, Mahak Bhargava, Luciane R Cavalli, Ritu Aneja

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shristi BhattaraiDepartment of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA 30144, USA.
Bruna M SugitaResearch Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.
Emanuelle Nunes-SouzaResearch Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.
Aline S FonsecaResearch Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.ORCID 0000-0002-0840-8487
Darshan Shimoga ChandrashekarMolecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-4295-9127
Mahak BhargavaDepartment of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-9495-9647
Luciane R CavalliResearch Institute Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.
Ritu AnejaDepartment of Biology, Georgia State University, Atlanta, GA 30302, USA.ORCID 0000-0003-4489-5320

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
HSET as a racial disparity biomarker for TNBC patientsR01CA239120 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANEJA, RITU · 2019 to 2024
$3.0M
NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA051008NCI NIH HHS R01 CA239120NCI NIH HHS R01CA239120
6 · The paper itself

Abstract

Androgen receptor (AR)-negative triple-negative breast cancer (TNBC), often termed quadruple-negative breast cancer (QNBC), disproportionately impacts women of African descent, leading to poorer overall survival (OS). MiRNAs regulate the expression of gene drivers involved in critical signaling pathways in TNBC, such as the

Indexed as

Black or African AmericanGene Expression Regulation, NeoplasticMicroRNAsReceptors, AndrogenTriple Negative Breast NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansMiddle AgedPrognosisWhiteAR protein, humanBiomarkers, TumorMicroRNAsReceptors, Androgenandrogen receptormiRNAprognosisquadruple negativeracetriple-negative breast cancer

Identifiers

PMID39769441
PMCPMC11679545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.