Evidence map›Paper›PMID 39769417›Full record

ArticleInternational journal of molecular sciences2024

Immune Cell Distributions in the Blood of Healthy Individuals at High Genetic Risk of Parkinson's Disease.

Laura Deecke, David Goldeck, Olena Ohlei, Jan Homann, Ilja Demuth, Lars Bertram, Graham Pawelec, Christina M Lill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura DeeckeInstitute of Epidemiology and Social Medicine, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.ORCID 0009-0002-9268-2469
David GoldeckDepartment of Immunology, University of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0001-6220-1527
Olena OhleiInstitute of Epidemiology and Social Medicine, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.ORCID 0009-0003-7721-6803
Jan HomannInstitute of Epidemiology and Social Medicine, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.ORCID 0000-0003-2791-7065
Ilja DemuthDepartment of Endocrinology and Metabolic Diseases (Including Division of Lipid Metabolism), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-4340-2523
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-0108-124X
Graham PawelecDepartment of Immunology, University of Tübingen, 72076 Tübingen, Germany.ORCID 0000-0002-3600-0163
Christina M LillInstitute of Epidemiology and Social Medicine, University of Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.ORCID 0000-0002-2805-1307

Funding

Deutsche Forschungsgemeinschaft LI 2654/4-1Federal Ministry of Education and Research #16SV5536K, #16SV5537, #16SV5538, #16SV5837, #01UW0808,01GL1716A, and 01GL1716B
6 · The paper itself

Abstract

The immune system likely plays a key role in Parkinson's disease (PD) pathophysiology. Thus, we investigated whether immune cell compositions are already altered in healthy individuals at high genetic risk for PD. We quantified 92 immune cell subtypes in the blood of 442 individuals using multicolor flow cytometry. Polygenic risk scores (PGS) for PD were calculated based on genome-wide significant SNPs (

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyParkinson DiseasePolymorphism, Single NucleotideAdultAgedFemaleHumansMaleMiddle AgedMultifactorial InheritanceRisk Factorsdisease predictionimmune systemneurodegenerationParkinson’s diseasepolygenic risk score

Identifiers

PMID39769417
PMCPMC11728367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.