Evidence map›Paper›PMID 39769414›Full record

ArticleInternational journal of molecular sciences2024

Expression Levels of MUC5AC and MUC5B in Airway Goblet Cells Are Associated with Traits of COPD and Progression of Chronic Airflow Limitation.

Terezia Pincikova, Heta Merikallio, Ioanna Kotortsi, Reza Karimi, Chuan-Xing Li, Elisa Lappi-Blanco, Sara K Lindén, Médea Padra, Åsa M Wheelock, Sven Nyrén and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Terezia PincikovaRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Heta MerikallioResearch Unit of Biomedicine and Internal Medicine, University of Oulu, 902 20 Oulu, Finland.ORCID 0000-0002-0967-3987
Ioanna KotortsiRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Reza KarimiRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Chuan-Xing LiRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Elisa Lappi-BlancoCancer and Translational Medicine Research Unit, Department of Pathology, Oulu University Hospital and University of Oulu, 902 20 Oulu, Finland.
Sara K LindénDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.ORCID 0000-0002-7751-9586
Médea PadraDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Åsa M WheelockRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Sven NyrénDepartment of Molecular Medicine and Surgery, Division of Radiology, Karolinska Institute, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.
Carl Magnus SköldRespiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institute, 171 76 Stockholm, Sweden.
Riitta L KaarteenahoResearch Unit of Biomedicine and Internal Medicine, University of Oulu, 902 20 Oulu, Finland.

Funding

A state subsidy of Oulu University Hospital NAERS-EU RESPIRE2 MCF [7214]-2013Hesselmans Foundation CMS 2010Karolinska Institutet NAKing Gustaf V's and Queen Victoria's Freemasons' Foundation CMS 2011, 2012, 2013Sandoz A/S CMS 2013The Foundation of the Finnish Anti-Tuberculosis Association NAThe Jalmari and Rauha Ahokas Foundation NAThe Regional Agreement on Medical Training and Clinical Research (ALF) between Stockholm County Council and Karolinska Institutet CMS 20110434, 20130051, 20150061, 20170393 and 20200287The Research Foundation of the Pulmonary Diseases NAThe Swedish Cancer- and Allergy Foundation CMS 071217The Swedish Heart-Lung Foundation CMS 20100435, 20130293, 20160418, 20180235, 20190320; SL 20230626The Swedish Research Council 2017-01142, 2018-00520 and 2021-02542The Swedish Respiratory Society CMS 2016
6 · The paper itself

Abstract

Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway's mucus gel. We retrieved bronchial mucosal biopsies and bronchial wash (BW) samples through bronchoscopy from patients with chronic obstructive pulmonary disease (

Indexed as

Disease ProgressionGoblet CellsMucin 5ACMucin-5BPulmonary Disease, Chronic ObstructiveAgedFemaleHumansMaleMiddle AgedSmokingMUC5AC protein, humanMUC5B protein, humanMucin 5ACMucin-5BCOPDepitheliumimmunohistochemistrymucinsmoking

Identifiers

PMID39769414
PMCPMC11678853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.