Evidence map›Paper›PMID 39769367›Full record

ArticleInternational journal of molecular sciences2024

Characterization of Dendritic Cells and Myeloid-Derived Suppressor Cells Expressing Major Histocompatibility Complex Class II in Secondary Lymphoid Organs in Systemic Lupus Erythematosus-Prone Mice.

Felipe R Uribe, Fabián González-Martínez, Sebastián A Echeverría-Araya, Alison Sepúlveda-Pontigo, Karissa Chávez-Villacreses, Andrés Díaz-Bozo, Isabel Méndez-Pérez, Valentina P I González, Karen Bohmwald, Alexis M Kalergis and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Felipe R UribeMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0009-0007-4695-0107
Fabián González-MartínezMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0009-0006-7232-1227
Sebastián A Echeverría-ArayaMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0000-0002-9911-7035
Alison Sepúlveda-PontigoMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.
Karissa Chávez-VillacresesMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.
Andrés Díaz-BozoMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0009-0005-9861-002X
Isabel Méndez-PérezMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.
Valentina P I GonzálezMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0009-0002-4252-8965
Karen BohmwaldInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago 8900000, Chile.ORCID 0000-0002-6794-7544
Alexis M KalergisMillennium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8330025, Chile.ORCID 0000-0001-7622-5263
Jorge A SotoMillennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.ORCID 0000-0003-0335-9759

Funding

Agencia Nacional de Investigación y Desarrollo (ANID) 11221280Agencia Nacional de Investigación y Desarrollo (ANID) 1231866Beca Doctorado Nacional ANID 21240988Millennium Institute on Immunology and Immunotherapy CN09_016 / ICN 2021_045; former P09/016-FPrograma de Atracción e Inserción de capital humano avanzado (PAI) SA77210051
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by self-antibody production and widespread inflammation affecting various body tissues. This disease is driven by the breakdown of immune tolerance, which promotes the activation of autoreactive B and T cells. A key feature of SLE is dysregulation in antigen presentation, where antigen-presenting cells (APCs) play a central role in perpetuating immune responses. Dendritic cells (DCs) are highly specialized for antigen presentation among APCs. At the same time, myeloid-derived suppressor cells (MDSCs) can also express MHC-II molecules, although their role in SLE is less understood. Utilizing the SLE model, MRL/MpJ-

Indexed as

Dendritic CellsHistocompatibility Antigens Class IILupus Erythematosus, SystemicMyeloid-Derived Suppressor CellsAnimalsDisease Models, AnimalFemaleInducible T-Cell Co-Stimulator LigandLymphoid TissueMiceSpleenHistocompatibility Antigens Class IIInducible T-Cell Co-Stimulator Ligandco-stimulatory moleculesdendritic cells (DCs)innate immunitymajor histocompatibility complex class II (MHC-II)MRL/MpJ-Faslpr/Jmyeloid-derived suppressor cells (MDSCs)systemic lupus erythematosus (SLE)

Identifiers

PMID39769367
PMCPMC11676837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.