Evidence map›Paper›PMID 39769348›Full record

ArticleInternational journal of molecular sciences2024

The Role of Flavonoids from Aurantii Fructus Immaturus in the Alleviation of Allergic Asthma: Theoretical and Practical Insights.

Jingwen Xue, Yuntong Liu, Qiushi Chen, Huimin Liu, Huijing Zhang, Bo Wang, Yongri Jin, Xuwen Li, Xiaolei Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Flavonoids as potential anti-asthmatic agents.Frontiers in immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingwen XueCollege of Food Science and Engineering, Jilin University, Changchun 130062, China.
Yuntong LiuCollege of Chemistry, Jilin University, Changchun 130012, China.ORCID 0009-0002-3267-6032
Qiushi ChenCollege of Food Science and Engineering, Jilin University, Changchun 130062, China.
Huimin LiuCollege of Food Science and Engineering, Jilin University, Changchun 130062, China.
Huijing ZhangCollege of Chemistry, Jilin University, Changchun 130012, China.
Bo WangCollege of Chemistry, Jilin University, Changchun 130012, China.ORCID 0000-0001-8104-1821
Yongri JinCollege of Chemistry, Jilin University, Changchun 130012, China.
Xuwen LiCollege of Chemistry, Jilin University, Changchun 130012, China.ORCID 0000-0002-3510-5908
Xiaolei ShiCollege of Food Science and Engineering, Jilin University, Changchun 130062, China.ORCID 0000-0001-8720-0256

Funding

Development Project of Jilin Provincial Department of Science and Technology No. 20240402024GHSocial Development Project of Jilin Provincial Department of Science and Technology No. 20220203171SF
6 · The paper itself

Abstract

Flavonoids derived from plants in the citrus family can have an alleviating effect on allergic asthma. The aim of this study was to provide insights into the mechanisms by which these compounds exert their effects on allergic asthma by combining theoretical and practical approaches. Aurantii Fructus Immaturus flavonoids (AFIFs) were obtained by solvent extraction and were determined by high performance liquid chromatography (HPLC). In vivo and in vitro experiments combined with network pharmacology, Mendelian randomization (MR) analysis and the AutoDock method were applied to study the mechanism of their effects. The main AFIFs were found to be hesperidin (13.21 mg/g), neohesperidin (287.26 mg/g), naringin (322.56 mg/g), and narirutin (19.35 mg/g). Based on the network pharmacology and MR analysis results, five targets Caspase 3 (CASP3), CyclinD1 (CCND1), Intercellular adhesion molecule (ICAM), erb-b2 receptor tyrosine kinase 2 (ERBB2), and rubisco accumulation factor 1 (RAF1) were selected, and the interactions between the AFIFs and the targets were studied using AutoDock Vina. The results indicated that glycosidic bonds play an important role in the interactions between AFIFs and both ERBB2 and RAF1.

Indexed as

AsthmaFlavonoidsHesperidinAnimalsCaspase 3CitrusDisaccharidesDrugs, Chinese HerbalFlavanonesHumansMiceMolecular Docking SimulationNetwork PharmacologyCaspase 3DisaccharidesDrugs, Chinese HerbalFlavanonesFlavonoidsfructus aurantii immaturusHesperidinnaringinnarirutinneohesperidinallergy and immunologycomputational biologyhypersensitivity

Identifiers

PMID39769348
PMCPMC11678185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.