Is Silver a Precious Metal for G-Quadruplex Stabilization Mediated by Porphyrins?

Nuno M M Moura, Sofia Guedes, Diana Salvador, Helena Oliveira, M Graça P M S Neves, Catarina I V Ramos

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nuno M M MouraLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-9373-7006

Sofia GuedesLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

Diana SalvadorCESAM-Centre for Environmental and Marine Studies, Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Helena OliveiraCESAM-Centre for Environmental and Marine Studies, Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-4673-0696

M Graça P M S NevesLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-7953-8166

Catarina I V RamosLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0002-0200-2005

Funding

Fundação para a Ciência e Tecnologia program DL 57/2016 - Norma transitória CDL-CTTRI-048-88-ARH/2018, CDL-CTTRI-047-88-ARH/2018, PhD grant (2022.11049.BD), Scientific Employment Stimulus (CEECIND/04050/2017), projects LAQV-REQUIMTE (LA/P/0008/2020 DOI 10.54499/LA/P/0008/2020, UIDP/50006/20

6 · The paper itself

Abstract

Cancer is a leading cause of death, so continuous efforts into cancer therapy are imperative. In tumor cells, telomerase and oncogene activity are key points for uncontrolled cell growth. Targeting these processes with ligands that inhibit telomerase and/or reduce oncogene expression has been identified as a promising cancer therapy. This study evaluated the selectivity and affinity of the silver

Indexed as

G-QuadruplexesPorphyrinsSilverCell Line, TumorHumansLigandsTelomereLigandsPorphyrinsSilvertetra(4-N-methylpyridyl)porphineG-quadruplexesH2TMPyPHaCaT cell linemetalloporphyrinsoncogene promotersPDTsilver complexsinglet oxygen generationtelomerase

Identifiers

PMID39769320

DOI10.3390/ijms252413556

PMCPMC11678824

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.