Evidence map›Paper›PMID 39769254›Full record

ArticleInternational journal of molecular sciences2024

The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients.

Abozer Y Elderdery, Hadeil M E Idris, Saud Nahar L Alruwaili, Entesar M Tebien, Abdullah Alsrhani, Fawaz O Alenazy, Badr Alzahrani, Emad Manni, Ahmed M E Elkhalifa, Jeremy Mills

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abozer Y ElderderyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.ORCID 0000-0002-6219-5312
Hadeil M E IdrisDepartment of Clinical Laboratory Science, College of Applied Medical Science, Shaqra University, Shaqra 15572, Saudi Arabia.
Saud Nahar L AlruwailiRegional Laboratory, Ministry of Health, Al-Jouf, Sakaka 72345, Saudi Arabia.ORCID 0009-0002-4347-1075
Entesar M TebienDepartment of Clinical Laboratory Science, College of Applied Medical Science, Shaqra University, Shaqra 15572, Saudi Arabia.ORCID 0000-0001-8635-8115
Abdullah AlsrhaniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.ORCID 0000-0002-6839-8866
Fawaz O AlenazyDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.ORCID 0000-0002-2860-5509
Badr AlzahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.
Emad ManniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 42421, Saudi Arabia.
Ahmed M E ElkhalifaDepartment of Public Health, College of Health Sciences, Saudi Electronic University, Riyadh 13316, Saudi Arabia.ORCID 0000-0002-2660-5054
Jeremy MillsSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK.ORCID 0000-0003-1719-9047

Funding

jouf University DGSSR-2023-01-02387
6 · The paper itself

Abstract

The most frequent type of leukemia in Africa is chronic myeloid leukemia (CML). The genetic background of the rarer Philadelphia chromosome (Ph) Ph-ve (BCR-ABL-ve) subform of CML is largely unknown in African patients. Therefore, in this study, we aimed to investigate the role of CYP1A1 and 2D6 SNPs in the pathogenesis of Ph-ve CML in the Sudanese population. A total of 126 patients were selected for analysis. DNA was isolated from Ph-ve CML patients and a control group for PCR-RFLP analysis of SNPs CYP1A1*2C and CYP2D6*4. The CYP1A1 gene significantly expressed the GG variant genotype (

Indexed as

Cytochrome P-450 CYP1A1Cytochrome P-450 CYP2D6Genetic Predisposition to DiseaseLeukemia, Myelogenous, Chronic, BCR-ABL PositivePhiladelphia ChromosomePolymorphism, Single NucleotideAdolescentAdultAgedCase-Control StudiesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedCYP1A1 protein, humanCytochrome P-450 CYP1A1Cytochrome P-450 CYP2D6CYP1A1CYP2D6CYP450cytochrome P450Ph-ve CMLSNPsSudanese population

Identifiers

PMID39769254
PMCPMC11728260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.