Evidence map›Paper›PMID 39769234›Full record

ReviewInternational journal of molecular sciences2024

A Critical Review on microRNAs as Prognostic Biomarkers in Laryngeal Carcinoma.

Kristina S Komitova, Lyuben D Dimitrov, Gergana S Stancheva, Silva G Kyurkchiyan, Veronika Petkova, Stoyan I Dimitrov, Silviya P Skelina, Radka P Kaneva, Todor M Popov

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristina S KomitovaDepartment of ENT, Medical University, 1000 Sofia, Bulgaria.
Lyuben D DimitrovDepartment of ENT, Medical University, 1000 Sofia, Bulgaria.
Gergana S StanchevaMolecular Medicine Center, Medical University, 1000 Sofia, Bulgaria.ORCID 0000-0003-4359-9618
Silva G KyurkchiyanMolecular Medicine Center, Medical University, 1000 Sofia, Bulgaria.
Veronika PetkovaMolecular Medicine Center, Medical University, 1000 Sofia, Bulgaria.
Stoyan I DimitrovDepartment of ENT, Medical University, 1000 Sofia, Bulgaria.ORCID 0000-0001-6769-3268
Silviya P SkelinaDepartment of Neurology, Medical University, 1000 Sofia, Bulgaria.
Radka P KanevaMolecular Medicine Center, Medical University, 1000 Sofia, Bulgaria.
Todor M PopovDepartment of ENT, Medical University, 1000 Sofia, Bulgaria.ORCID 0000-0002-8205-3573

Funding

European Union BG-RRP-2.004-0004-C01", group 3.1.5
6 · The paper itself

Abstract

During the past decade, a vast number of studies were dedicated to unravelling the obscurities of non-coding RNAs in all fields of the medical sciences. A great amount of data has been accumulated, and consequently a natural need for organization and classification in all subfields arises. The aim of this review is to summarize all reports on microRNAs that were delineated as prognostic biomarkers in laryngeal carcinoma. Additionally, we attempt to allocate and organize these molecules according to their association with key pathways and oncogenes affected in laryngeal carcinoma. Finally, we critically analyze the common shortcomings and biases of the methodologies in some of the published papers in this area of research. A literature search was performed using the PubMed and MEDLINE databases with the keywords "laryngeal carcinoma" OR "laryngeal cancer" AND "microRNA" OR "miRNA" AND "prognostic marker" OR "prognosis". Only research articles written in English were included, without any specific restrictions on study type. We have found 43 articles that report 39 microRNAs with prognostic value associated with laryngeal carcinoma, and all of them are summarized along with the major characteristics and methodology of the respective studies. A second layer of the review is structural analysis of the outlined microRNAs and their association with oncogenes and pathways connected with the cell cycle (

Indexed as

Biomarkers, TumorGene Expression Regulation, NeoplasticLaryngeal NeoplasmsMicroRNAsHumansPrognosisSignal TransductionBiomarkers, TumorMicroRNAsbiomarkerslaryngeal carcinomamicroRNAprognosissurvival

Identifiers

PMID39769234
PMCPMC11676902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.