Evidence map›Paper›PMID 39769232›Full record

ArticleInternational journal of molecular sciences2024

In Vivo Induction of Leukemia-Specific Adaptive and Innate Immune Cells by Treatment of AML-Diseased Rats and Therapy-Refractory AML Patients with Blast Modulating Response Modifiers.

Michael Atzler, Tobias Baudrexler, Daniel Christoph Amberger, Nicole Rogers, Alexander Rabe, Joerg Schmohl, Ruixiao Wang, Andreas Rank, Olga Schutti, Klaus Hirschbühl and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael AtzlerMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Tobias BaudrexlerMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Daniel Christoph AmbergerMedical Department III, Munich University Hospital, 81377 Munich, Germany.ORCID 0000-0002-5331-0884
Nicole RogersMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Alexander RabeMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Joerg SchmohlDiaconia Hospital Stuttgart, 70176 Stuttgart, Germany.
Ruixiao WangMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Andreas RankBavarian Cancer Research Center (BZKF), 80539 Munich, Germany.ORCID 0000-0002-5636-0043
Olga SchuttiMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Klaus HirschbühlBavarian Cancer Research Center (BZKF), 80539 Munich, Germany.
Marit InngjerdingenDepartment of Immunology, Oslo University, 0027 Oslo, Norway.
Diana DeenMedical Department III, Munich University Hospital, 81377 Munich, Germany.
Britta Eiz-VesperInstitute for Transfusion Medicine, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-8378-3298
Christoph SchmidBavarian Cancer Research Center (BZKF), 80539 Munich, Germany.ORCID 0000-0001-7070-487X
Helga Maria SchmetzerMedical Department III, Munich University Hospital, 81377 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a high medical need to develop new strategies for the treatment of patients with acute myeloid leukemia (AML) refractory to conventional therapy. In vitro, the combinations of the blast-modulatory response modifiers GM-CSF + Prostaglandin E1, (summarized as Kit M) have been shown to convert myeloid leukemic blasts into antigen-presenting dendritic cells of leukemic origin (DC

Indexed as

Adaptive ImmunityImmunity, InnateLeukemia, Myeloid, AcuteAdultAnimalsDendritic CellsFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansMaleMiddle AgedRatsRats, Inbred BNGranulocyte-Macrophage Colony-Stimulating FactorAMLAML immunotherapyimmune-monitoringkitsleukemia-derived dendritic cellsleukemia-specific cellsnew AML drugs

Identifiers

PMID39769232
PMCPMC11679655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.