Evidence map›Paper›PMID 39769133›Full record

ArticleInternational journal of molecular sciences2024

Bovine Lactoferrin Enhances Toll-like Receptor 7 Response in Plasmacytoid Dendritic Cells and Modulates Cellular Immunity.

Takumi Yago, Asuka Tada, Shutaro Kubo, Hirotsugu Oda, Sadahiro Iwabuchi, Miyuki Tanaka, Shinichi Hashimoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Special Issue "New Insights into Lactoferrin".International journal of molecular sciences · 2025
    Article
  6. A Comprehensive Review of the Bovine Immune Response to Pathogens.International journal of molecular sciences · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takumi YagoR&D Division, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.
Asuka TadaInternational Division, Morinaga Milk Industry Co., Ltd., Minato 105-7122, Japan.ORCID 0000-0003-2364-9462
Shutaro KuboR&D Division, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.
Hirotsugu OdaR&D Division, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.
Sadahiro IwabuchiDepartment of Molecular Pathophysiology, Wakayama Medical University, Wakayama 641-8509, Japan.ORCID 0000-0003-0434-3054
Miyuki TanakaR&D Division, Morinaga Milk Industry Co., Ltd., Zama 252-8583, Japan.ORCID 0000-0002-7670-7366
Shinichi HashimotoDepartment of Molecular Pathophysiology, Wakayama Medical University, Wakayama 641-8509, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmacytoid dendritic cells (pDCs) express Toll-like receptor 7 (TLR7) in the endosomes, recognize viral single-stranded RNA (ssRNA), and produce significant amounts of interferon (IFN)-α. Bovine lactoferrin (LF) enhances the response of IFN regulatory factors followed by the activation of IFN-sensitive response elements located in the promoter regions of the

Indexed as

Dendritic CellsLactoferrinToll-Like Receptor 7AnimalsCattleHumansImidazolesImmunity, CellularInterferon-alphaLeukocytes, MononuclearTHP-1 CellsImidazolesInterferon-alphaLactoferrinresiquimodTLR7 protein, humanToll-Like Receptor 7bovine lactoferrinimmune cellsinterferonperipheral blood mononuclear cellsplasmacytoid dendritic cellstoll-like receptor 7

Identifiers

PMID39769133
PMCPMC11676446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.