Evidence map›Paper›PMID 39769016›Full record

ArticleInternational journal of molecular sciences2024

Advancing Immunoassay Precision: A Novel Preanalytical Method for Enhancing Thyroglobulin Measurement in the Presence of Tg Antibodies.

Ilona Đorić, Aleksandra Todorović, Marija Gnjatović, Snežana Golubović, Miloš Žarković, Jelena Janković Miljuš, Tijana Išić Denčić, Sonja Šelemetjev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilona ĐorićInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.ORCID 0000-0001-5322-4559
Aleksandra TodorovićInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Marija GnjatovićInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Snežana GolubovićInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Miloš ŽarkovićClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Doktora Subotića 13, 11000 Belgrade, Serbia.
Jelena Janković MiljušInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.
Tijana Išić DenčićInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.ORCID 0000-0001-8475-2266
Sonja ŠelemetjevInstitute for the Application of Nuclear Energy INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.ORCID 0000-0002-2898-6671

Funding

Serbia Accelerating Innovation and Entrepreneurship (SAIGE) Project, a joint investment by the Ministry of Science, Technological Development and Innovation of the Republic of Serbia, the World Bank and the European Union. 03-514/1
6 · The paper itself

Abstract

Thyroglobulin (Tg) is a reliable marker for detecting recurrence in differentiated thyroid cancer (DTC) patients, but frequently occurring Tg antibodies (TgAbs) can hinder accurate measurement. We aimed to develop a preanalytical protocol for precise Tg detection in TgAb presence using the immunoradiometric assay (IRMA) platform. This study involved forty-five patients who underwent IRMA Tg and radioimmunoassay (RIA) TgAb measurements, including two patients monitored for recurrence and one with confirmed recurrence. All three had undetectable Tg levels. We evaluated three preanalytical methods in aiming to separate Tg from TgAbs: buffer only (Protocol 1), micro-spin filters only (Protocol 2), and a combination of both (Protocol 3). All preanalytical protocols showed high concordance with the original test (r = 0.981, 0.985, 0.971, respectively,

Indexed as

AutoantibodiesThyroglobulinThyroid NeoplasmsAdultAgedFemaleHumansImmunoassayImmunoradiometric AssayMaleMiddle AgedRadioimmunoassayanti-thyroglobulinAutoantibodiesThyroglobulinDTC follow-upIRMApreanalytical treatmentrecurrent DTCTgTgAb interferenceTg immunoassays

Identifiers

PMID39769016
PMCPMC11675399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.