ReviewLife (Basel, Switzerland)2024
Neonatal Hypoglycemia and Neurodevelopmental Outcomes-An Updated Systematic Review and Meta-Analysis.
Review in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reference ranges of blood glucose values in healthy term neonates in their first days of life: a systematic review and meta-analysis.European journal of pediatrics · 2025Pooled it
- Late preterm hypoglycemia through the lens of long-term evidence.Pediatric research · 2026Article
- Neonatal Hypoglycemia: A Systematic Review of International and Local Clinical Guidelines with Clinical Implications.Journal of clinical medicine · 2026Review
- Fetal size, gestational age, and cognitive performance at 5 years in term-born children: Four national cohorts' study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Article
- sFlt-1/PlGF Ratio as a Central Biomarker for Preeclampsia and Perinatal Outcomes: A Multisystem Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Implementation of a Hybrid Closed-Loop Automated Insulin Delivery System in a 29-Day Infant With Neonatal Diabetes.JCEM case reports · 2026Article
- Neurobehavioral outcomes at 12 months in very preterm infants monitored with continuous glucose monitoring at birth compared with full-term infants.Scientific reports · 2026Article
- Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.Neurophotonics · 2026Article
- Investigating brain haemodynamics during hypoglycaemia in very preterm neonates using diffuse optical tomography.medRxiv : the preprint server for health sciences · 2025Article
- Neurological Outcomes in Late Preterm Infants: An Updated Review of Recent Research and Clinical Insights.Diagnostics (Basel, Switzerland) · 2025Review
- Neonatal Hypoglycemia and Long-Term Pediatric Neurodevelopmental Outcomes: A Systematic Review.Cureus · 2025Review
- Incidence and risk factors of neonatal hypoglycemia at Hawassa University Comprehensive Specialized Hospital.PloS one · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe effects of neonatal hypoglycemia on the developing brain are well known, resulting in poor neurological outcomes. We aimed to perform an updated meta-analysis on neonatal hypoglycemia, the severity of hypoglycemia, and the associated neurodevelopmental outcomes from infancy to adulthood.
methodsA systematic literature search was conducted from inception until March 2024, using the PubMed, CINAHL, Embase, and the CENTRAL databases. Randomized/quasi-randomized trials and observational studies that evaluated at least one of the pre-specified outcomes were included. A random-effects model meta-analysis was performed to yield the pooled OR and its 95% CI for each outcome due to the expected heterogeneity in the studies. The study findings were reported as per the PRISMA guidelines. Neurodevelopmental impairment (NDI), cognitive impairment, and visual-motor or visual impairment were the primary outcomes.
resultsA total of 17 studies (19 publications) were included in the final analysis. NDI, as defined by authors, was significantly higher in early- (OR = 1.16; 95% CI = 1.11-1.43) and mid-childhood (OR = 3.67; 95%CI = 1.07-12.2) in infants with neonatal hypoglycemia. 'Any cognitive impairment' was significantly more common in infants with neonatal hypoglycemia (OR = 2.12; 95%CI = 1.79-2.52). Visual-motor impairment (OR = 3.33; 95%CI = 1.14-9.72) and executive dysfunction (OR = 1.99; 95%CI = 1.36-2.91) were also more common in the hypoglycemic group. No difference in the incidence of epilepsy, motor impairment, emotional-behavioral problems, or hearing impairment were noted. Certainty of evidence was adjudged as 'low' to 'very low' for most outcomes. The severity of hypoglycemia was studied at different intervals, with NDI more common with a blood glucose interval between 20 and 34 mg/dL (1.1-1.9 mmol/L).
conclusionsLow-quality evidence from large observational studies finds a significant association with hypoglycemia in the early neonatal period and long-term neurodevelopmental problems. Additional studies with long enough follow-up are paramount to determine the cut-off concentration and to quantify the impact beyond the infancy period.
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