Evidence map›Paper›PMID 39768254›Full record

ArticleLife (Basel, Switzerland)2024

Enhancing the Chemosensitivity of MKN-45 Gastric Cancer Cells to Docetaxel via

Elif Sibel Aslan, Nermin Akcali, Cuneyd Yavas, Sajjad Eslamkhah, Savas Gur, Lutfiye Karcioglu Batur

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elif Sibel AslanFaculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Biruni University, Istanbul 34015, Türkiye.ORCID 0000-0002-3081-9004
Nermin AkcaliFaculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Biruni University, Istanbul 34015, Türkiye.ORCID 0000-0001-6816-9687
Cuneyd YavasFaculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Biruni University, Istanbul 34015, Türkiye.
Sajjad EslamkhahFaculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Biruni University, Istanbul 34015, Türkiye.
Savas GurInternal Medicine Specialist, Private Clinic, Çanakkale 17100, Türkiye.
Lutfiye Karcioglu BaturFaculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Biruni University, Istanbul 34015, Türkiye.ORCID 0000-0002-4803-9137

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough chemotherapy is one of the standard treatments for gastric cancer, the disease's resistance mechanisms continue to limit the survival rates. MATERIALS AND

methodsIn this study, MKN-45 gastric cancer cells were transfected for 24 h with siRNA targeting

resultsThe sensitivity of MKN-45 cells to docetaxel was greatly increased by the siRNA-mediated knockdown of

conclusions

Indexed as

B7H6 suppressionchemosensitivitydocetaxelgastric cancersiRNA-mRNA

Identifiers

PMID39768254
PMCPMC11676808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.