Evidence map›Paper›PMID 39768215›Full record

ArticleCells2024

GPR68 Mediates Lung Endothelial Dysfunction Caused by Bacterial Inflammation and Tissue Acidification.

Pratap Karki, Yunbo Ke, Chenou Zhang, Kamoltip Promnares, Yue Li, Charles H Williams, Charles C Hong, Konstantin G Birukov, Anna A Birukova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pratap KarkiDivision of Pulmonary and Critical Care, Department of Medicine, UMSOM Lung Biology Program, University of Maryland School of Medicine, 20 Penn Street, HSF-2, Room S143, Baltimore, MD 21201, USA.ORCID 0000-0002-3087-5516
Yunbo KeDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Chenou ZhangDivision of Pulmonary and Critical Care, Department of Medicine, UMSOM Lung Biology Program, University of Maryland School of Medicine, 20 Penn Street, HSF-2, Room S143, Baltimore, MD 21201, USA.
Kamoltip PromnaresDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Yue LiDivision of Pulmonary and Critical Care, Department of Medicine, UMSOM Lung Biology Program, University of Maryland School of Medicine, 20 Penn Street, HSF-2, Room S143, Baltimore, MD 21201, USA.
Charles H WilliamsDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Charles C HongDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0424-8252
Konstantin G BirukovDepartment of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-0303-5394
Anna A BirukovaDivision of Pulmonary and Critical Care, Department of Medicine, UMSOM Lung Biology Program, University of Maryland School of Medicine, 20 Penn Street, HSF-2, Room S143, Baltimore, MD 21201, USA.

Funding

GPR68 as a novel modulator of septic lung injuryR01HL167192 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Anna Birukova, CHARLES C HONG · 2023 to 2026
$2.4M
Control of septic inflammation and lung microvascular endothelial barrier by cell junction signaling nexusR01HL152761 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOVA, ANNA · 2021 to 2024
$2.2M
Mechanisms of microvascular endothelial cell injury caused by extracellular histonesR01HL155051 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI BIRUKOVA, ANNA · 2021 to 2024
$1.8M
NHLBI NIH HHS R01 HL152761NHLBI NIH HHS R01 HL155051NHLBI NIH HHS R01 HL167192NHLBI NIH HHS RO1HL167192 (A.A.B., C.C.H.)RO1HL152761, RO1HL155051 (A.A.B.).
6 · The paper itself

Abstract

Tissue acidification resulting from dysregulated cellular bioenergetics accompanies various inflammatory states. GPR68, along with other members of proton-sensing G protein-coupled receptors, responds to extracellular acidification and has been implicated in chronic inflammation-related diseases such as ischemia, cancer, and colitis. The present study examined the role of extracellular acidification on human pulmonary endothelial cell (EC) permeability and inflammatory status per se and investigated potential synergistic effects of acidosis on endothelial dysfunction caused by bacterial lipopolysaccharide (LPS,

Indexed as

Endothelial CellsInflammationLungReceptors, G-Protein-CoupledHumansHydrogen-Ion ConcentrationIntercellular Adhesion Molecule-1LipopolysaccharidesGPR68 protein, humanIntercellular Adhesion Molecule-1LipopolysaccharidesReceptors, G-Protein-Coupledacidosisendothelial permeabilityGPR4GPR68inflammationLPSOGM-8345

Identifiers

PMID39768215
PMCPMC11674861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.