Evidence map›Paper›PMID 39768211›Full record

ArticleCells2024

Mechanistic Insights into the Adenosine A1 Receptor's Positive Allosteric Modulation for Non-Opioid Analgesics.

Tal Weizmann, Abigail Pearce, Peter Griffin, Achille Schild, Maren Flaßhoff, Philipp Grossenbacher, Martin Lochner, Christopher A Reynolds, Graham Ladds, Giuseppe Deganutti

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tal WeizmannCentre for Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK.
Abigail PearceDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Peter GriffinCentre for Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK.
Achille SchildInstitute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-7987-8013
Maren FlaßhoffInstitute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland.
Philipp GrossenbacherInstitute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0001-8266-6882
Martin LochnerInstitute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0003-4930-1886
Christopher A ReynoldsCentre for Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK.ORCID 0000-0001-9267-5141
Graham LaddsDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.ORCID 0000-0001-7320-9612
Giuseppe DeganuttiCentre for Health and Life Sciences, Coventry University, Coventry CV1 5FB, UK.ORCID 0000-0001-8780-2986

Funding

Biotechnology and Biological Sciences Research Council BB/W014831/1Biotechnology and Biological Sciences Research Council BB/W016974/1
6 · The paper itself

Abstract

The adenosine A1 receptor (A

Indexed as

Molecular Dynamics SimulationReceptor, Adenosine A1AdenosineAdenosine A1 Receptor AgonistsAllosteric RegulationAllosteric SiteAnalgesics, Non-NarcoticAnimalsHumansAdenosineAdenosine A1 Receptor AgonistsAnalgesics, Non-NarcoticReceptor, Adenosine A1adenosine A1 receptorBnOCPAGPCRsMIPS521non-opioid analgesia

Identifiers

PMID39768211
PMCPMC11726717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.