Nuclear Factor-κB Signaling Regulates the Nociceptin Receptor but Not Nociceptin Itself.

Lan Zhang, Ulrike M Stamer, Robin Moolan-Vadackumchery, Frank Stüber

Abstract read

In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lan ZhangDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Ulrike M StamerDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8385-2249

Robin Moolan-VadackumcheryDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Frank StüberDepartment of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-3113-7088

Funding

Foundation for Research in Anaesthesiology and Intensive Care Medicine, Inselspital, University of Bern 140-ZHLF-1-19

6 · The paper itself

Abstract

The nociceptin receptor (NOP) and nociceptin are involved in the pathways of pain and inflammation. The potent role of nuclear factor-κB (NFκB) in the modulation of tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β on the nociceptin system in human THP-1 cells under inflammatory conditions were investigated. Cells were stimulated without/with phorbol-myristate-acetate (PMA), TNF-α, IL-1β, or PMA combined with individual cytokines. To examine NFκB's contribution to the regulation of the nociceptin system, PMA-stimulated cells were treated with NFκB inhibitor BAY 11-7082, JSH-23, or anacardic acid before culturing with TNF-α or IL-1β.

Indexed as

Interleukin-1betaNF-kappa BNociceptinNociceptin ReceptorReceptors, OpioidSignal TransductionTumor Necrosis Factor-alphaHumansNitrilesOpioid PeptidesPhosphorylationProtein PrecursorsSulfonesTetradecanoylphorbol AcetateTHP-1 CellsTranscription Factor RelA3-(4-methylphenylsulfonyl)-2-propenenitrileInterleukin-1betaNF-kappa BNitrilesNociceptinNociceptin ReceptorOpioid PeptidesOPRL1 protein, humanprepronociceptinProtein PrecursorsReceptors, OpioidSulfonesTetradecanoylphorbol AcetateTranscription Factor RelATumor Necrosis Factor-alphacell culturescytokinesNFκBnociceptinnociceptin receptorsignal transduction

Identifiers

PMID39768201

DOI10.3390/cells13242111

PMCPMC11674636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.