Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization.
Yong-Seok Song, Shoujian Wang, SunYoung Park, Barbara Hanna, Kelsey J Johnson, Soesiawati R Darjatmoko, Mohammad Ali Saghiri, Ali Mohammad Saghiri, Bo Liu, Christine M Sorenson and 1 more
Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Yong-Seok SongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Shoujian WangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
SunYoung ParkDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Barbara HannaDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Kelsey J JohnsonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Soesiawati R DarjatmokoDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Mohammad Ali SaghiriDepartment of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, NJ 07103, USA.ORCID 0000-0002-5064-7828
Ali Mohammad SaghiriDepartment of Computer Science, William Paterson University, Wayne, NJ 07470, USA.ORCID 0000-0003-0797-314X
Bo LiuDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.ORCID 0000-0003-2723-9217
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
Novel Role of Thrombospondin-1 in Protection against Rupture of Abdominal Aortic AneurysmR01HL158073 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LIU, BO · 2021 to 2024
$1.9M
VEGF Antagonism and Resistance to Neovascular AMDR01EY030076 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2020 to 2023
$1.5M
Bcl-2, Subretinal Scar Formation and Neovascular AMDR21EY034646 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2023 to 2023
$428k
Carl Marshall Reeves &Mildred Almen Reeves Foundation Research GrantMeriter Foundation (UNITE) GiftNCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY030076NEI NIH HHS R21 EY034646NHLBI NIH HHS R01 HL158073NIH/NEI EY030076NIH/NEI EY034646NIH/NIHLB HL158073NSF DMR-2312680NSF STTR-2321456Pat and Jay Smith AMD Innovation Fund Research GrantResearch to Prevent Blindness Untrestricted award to the Department of Ophthalmology and Visual SciencesRetina Research Foundation EndoumentRRF/Daniel M. Albert Chair Endoument
6 · The paper itself
Abstract
Functional cell death pathways are essential for normal ocular vascular development and tissue homeostasis. As our understanding of necrosis-based cell death pathways has expanded, the inclusion of regulated forms, including necroptosis, ferroptosis, and oxytosis, has occurred. Although the existence of these pathways is well described, our understanding of their role during vascular development and pathological neovascularization is very limited. Here, we examined the role of receptor-interacting protein kinase-3 (Ripk3), a key regulator of necroptosis, in postnatal retinal vascularization and retinal and choroidal neovascularization under pathological conditions. Postnatal vascularization of the retinal superficial layer in the absence of Ripk3 (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Receptor-Interacting Protein Kinase-3 Expression Impacts Ocular Vascular Development and Pathological Neovascularization. · full record | OpenQuestion