Evidence map›Paper›PMID 39768195›Full record

ArticleCells2024

The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood-Brain Barrier in the Course of Pneumococcal Meningitis.

Johannes Deutloff, Irina Pöhner, Johann Rößler, Markus Kipp, Simone C Tauber, Lars-Ove Brandenburg

Abstract read
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In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johannes DeutloffInstitute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.
Irina PöhnerInstitute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.
Johann RößlerInstitute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.
Markus KippInstitute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.ORCID 0000-0001-5043-9052
Simone C TauberDepartment of Neurology, RWTH University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
Lars-Ove BrandenburgInstitute of Anatomy, Rostock University Medical Center, Rostock, Gertrudenstraße 9, 18057 Rostock, Germany.ORCID 0000-0002-6126-8153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe brain is protected from invading pathogens by the blood-brain barrier (BBB) and the innate immune system. Pattern recognition receptors play a crucial role in detecting bacteria and initiating the innate immune response. Among these are G-protein-coupled formyl peptide receptors (FPR), which are expressed by immune cells in the central nervous system. In this study, we investigated the influence of the FPR ligand Ac2-26 on the integrity of the BBB during pneumococcal meningitis.

methodsWild-type (WT) and Fpr1- and Fpr2-deficient mice were intrathecally infected with

resultsThe results showed reduced BBB integrity during the course of bacterial meningitis. Treatment with Ac2-26 in WT mice significantly prolonged the maintenance of BBB integrity. However, this effect was not observed in Fpr2-deficient mice.

conclusionsThis study extends previous findings on the anti-inflammatory properties of Ac2-26 by demonstrating that Ac2-26 positively affects BBB integrity via FPR2 during pneumococcal meningitis. These findings suggest that further investigation of Ac2-26 and other FPR modulators as potential therapies for

Indexed as

Blood-Brain BarrierMeningitis, PneumococcalReceptors, Formyl PeptideAnimalsLigandsMiceMice, Inbred C57BLMice, KnockoutOligopeptidesStreptococcus pneumoniaeformyl peptide receptor 2, mouseFpr1 protein, mouseLigandsOligopeptidesReceptors, Formyl Peptidetryptophyl-arginyl-tryptophyl-tryptophyl-tryptophyl-tryptophanamideannexin A1bacterial meningitisblood-brain barrierformyl peptide receptorinnate immunityStreptococcus pneumoniae

Identifiers

PMID39768195
PMCPMC11674053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.