Evidence map›Paper›PMID 39768179›Full record

ReviewCells2024

Modeling Viral Capsid Assembly: A Review of Computational Strategies and Applications.

Wenhan Guo, Esther Alarcon, Jason E Sanchez, Chuan Xiao, Lin Li

Abstract readReview
In one paragraph

Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenhan GuoDepartment of Physics, University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0002-6767-075X
Esther AlarconDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX 79968, USA.
Jason E SanchezDepartment of Computational Science, University of Texas at El Paso, El Paso, TX 79968, USA.
Chuan XiaoDepartment of Chemistry and Biochemistry, University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0001-6599-8762
Lin LiDepartment of Physics, University of Texas at El Paso, El Paso, TX 79968, USA.ORCID 0000-0001-6447-2398

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI RENATO J AGUILERA · 2019 to 2026
$35.1M
Deciphering the Molecular Assembly Mechanism of Giant DNA VirusesR01GM129525 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI XIAO, CHUAN · 2019 to 2023
$1.8M
Developing and applying large-scale simulation approach to understand the mechanisms of kinesins' motilities along microtubulesSC1GM132043 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI LI, LIN · 2019 to 2022
$1.5M
NIGMS NIH HHS R01 GM129525NIGMS NIH HHS SC1 GM132043NIH HHS SC1GM132043, R01GM129525, and U54MD007592NIMHD NIH HHS U54 MD007592Welch Foundation AH-2126-20220331
6 · The paper itself

Abstract

Viral capsid assembly is a complex and critical process, essential for understanding viral behavior, evolution, and the development of antiviral treatments, vaccines, and nanotechnology. Significant progress in studying viral capsid assembly has been achieved through various computational approaches, including molecular dynamics (MD) simulations, stochastic dynamics simulations, coarse-grained (CG) models, electrostatic analyses, lattice models, hybrid techniques, machine learning methods, and kinetic models. Each of these techniques offers unique advantages, and by integrating these diverse computational strategies, researchers can more accurately model the dynamic behaviors and structural features of viral capsids, deepening our understanding of the assembly process. This review provides a comprehensive overview of studies on viral capsid assembly, emphasizing their critical role in advancing our knowledge. It examines the contributions, strengths, and limitations of different computational methods, presents key computational works in the field, and analyzes milestone studies that have shaped current research.

Indexed as

CapsidVirus AssemblyCapsid ProteinsHumansMolecular Dynamics SimulationCapsid Proteinscoarse-grained modelscomputational methodsmolecular dynamics simulationsviral capsid assembly

Identifiers

PMID39768179
PMCPMC11674207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.