Evidence map›Paper›PMID 39768143›Full record

ArticleCells2024

Attempts to Create Transgenic Mice Carrying the Q3924E Mutation in RyR2 Ca

Xiao-Hua Zhang, Fu-Lei Tang, Allison M Trouten, Martin Morad

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Characterization of cardiac disease-associated mutations in RyR2 CaAmerican journal of physiology. Cell physiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Hua ZhangCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.ORCID 0000-0002-2139-7065
Fu-Lei TangDepartment of Comparative Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0003-2102-1137
Allison M TroutenDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Martin MoradCardiac Signaling Center, University of South Carolina, Medical University of South Carolina and Clemson University, Charleston, SC 29425, USA.ORCID 0000-0002-9054-0195

Funding

Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesR01HL153504 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL153504NIH HHS R01HL153504
6 · The paper itself

Abstract

Over 200 point mutations in the ryanodine receptor (RyR2) of the cardiac sarcoplasmic reticulum (SR) are known to be associated with cardiac arrhythmia. We have already reported on the calcium signaling phenotype of a point mutation in RyR2 Ca

Indexed as

CalciumMice, TransgenicMyocytes, CardiacRyanodine Receptor Calcium Release ChannelAnimalsBinding SitesCaffeineCalcium SignalingCRISPR-Cas SystemsFemaleHumansMiceMutationCaffeineCalciumryanodine receptor 2. mouseRyanodine Receptor Calcium Release ChannelhiPSC-CMsRyR2 Q3924E mousesarcoplasmic reticulumsudden death

Identifiers

PMID39768143
PMCPMC11674951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.