Evidence map›Paper›PMID 39768017›Full record

ReviewBioengineering (Basel, Switzerland)2024

3D Culture of MSCs for Clinical Application.

Qi Gao, Mehmet Sertac Cekuc, Yasemin Sude Ergul, Alexa K Pius, Issei Shinohara, Masatoshi Murayama, Yosuke Susuki, Chao Ma, Mayu Morita, Simon Kwoon-Ho Chow and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qi GaoDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0003-0175-566X
Mehmet Sertac CekucDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-8068-7820
Yasemin Sude ErgulDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-1683-9439
Alexa K PiusDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.
Issei ShinoharaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-4122-7119
Masatoshi MurayamaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.
Yosuke SusukiDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.
Chao MaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-1049-6172
Mayu MoritaDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.
Simon Kwoon-Ho ChowDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0003-1742-980X
Stuart B GoodmanDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA 94304, USA.ORCID 0000-0002-1919-3717

Funding

Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic ComplicationsUG3TR002136 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUAN, ROCKY S · 2017 to 2018
$2.5M
Neurophysiology of Weakness and Exercise in Rotator Cuff TendinopathyR01AR063713 · NIAMS · UNIVERSITY OF OREGON · PI KARDUNA, ANDREW ROBERT · 2014 to 2018
$1.7M
Customized MSCs to Enhance Healing of Bone DefectsR01AR073145 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2018 to 2021
$1.4M
NCATS NIH HHS UG3 TR002136NIAMS NIH HHS R01 AR063713NIAMS NIH HHS R01 AR073145NIH HHS R01 AR063713NIH HHS R01 AR073145NIH HHS UG3TR002136Stanford University the Ellenburg Chair in Surgery
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) play an important role in regenerative medicine and drug discovery due to their multipotential differentiation capabilities and immunomodulatory effects. Compared with traditional 2D cultures of MSCs, 3D cultures of MSCs have emerged as an effective approach to enhance cell viability, proliferation, and functionality, and provide a more relevant physiological environment. Here, we review the therapeutic potential of 3D-cultured MSCs, highlighting their roles in tissue regeneration and repair and drug screening. We further summarize successful cases that apply 3D MSCs in modeling disease states, enabling the identification of novel therapeutic strategies. Despite these promising applications, we discuss challenges that remain in the clinical translation of 3D MSC technologies, including stability, cell heterogeneity, and regulatory issues. We conclude by addressing these obstacles and emphasizing the need for further research to fully exploit the potential of 3D MSCs in clinical practice.

Indexed as

3D culture technologyin vivo trialsMSCs

Identifiers

PMID39768017
PMCPMC11726872

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.