ArticleChildren (Basel, Switzerland)2024
Deviant Peer Affiliation, Depression, and Adolescent Non-Suicidal Self-Injury: The Moderating Effect of the OXTR Gene rs53576 Polymorphism.
Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Whole Blood Transcriptome Analysis in Female Adolescents With Depression Accompanied by Nonsuicidal Self-Injury and Suicide Attempt.Depression and anxiety · 2026Observational
- Associations of menstrual characteristics with non-suicidal self-injury: results from six universities in China.BMC public health · 2025Article
- Longitudinal associations between relative deprivation and non-suicidal self-injury in early adolescents: a moderated mediation model.Frontiers in psychiatry · 2025Article
- Parental harsh parenting and non-suicidal self-injury among Chinese adolescents: the role of emotional uncontrollability, deviant peer affiliation, school disengagement, and self-control.Frontiers in psychiatry · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
backgroundAdolescent non-suicidal self-injury (NSSI) has emerged as a progressively widespread and significant public health concern on a global scale. Research has increasingly documented a positive linkage between deviant peer affiliation and adolescent NSSI; however, there is little known about the underlying moderating or mediating mechanism of NSSI. According to the gene × environment interaction perspective, the current study investigated the intermediary function of depression in linking deviant peer affiliation to NSSI among adolescents, while also considering the moderating effect of the OXTR gene rs53576 polymorphism on this intermediary process.
methodsA total of 469 adolescents (Mean
resultsMediation analyses suggested that the positive connection between deviant peer affiliation and adolescent NSSI was mediated by depression. Moreover, the moderated mediation analyses revealed that deviant peer affiliation increased depression levels, which in turn contributed to increased NSSI among adolescents with the AA genotype. Nevertheless, the correlation failed to reach statistical significance among adolescents possessing the GA and GG genotypes.
conclusionsThese findings emphasize depression's potential as a bridge linking deviant peer affiliation to adolescent NSSI. The AA genotype of the OXTR gene rs53576 emerges as a critical risk factor in the enhancement of this indirect effect. This study provides valuable perspectives for designing intervention strategies aimed at reducing adolescent NSSI.
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