ReviewChildren (Basel, Switzerland)2024
Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review.
Raffaele Falsaperla, Rosanna Zanai, Ausilia Desiree Collotta, Vincenzo Sortino, Giovanna Vitaliti, Carla Cimino, Bruna Scalia, Marco Simone Vaccalluzzo, Michela Spatuzza, Grete Francesca Privitera and 5 more
Abstract readReview
In one paragraphReview in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Raffaele FalsaperlaNeonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.ORCID 0000-0002-4482-3506 Rosanna ZanaiCardiovascular Department, Mediterranean Pediatric Cardiology Center, Bambino Gesù Children's Hospital, 98035 Taormina, Italy.ORCID 0000-0002-5703-5410 Ausilia Desiree CollottaPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.ORCID 0000-0003-4200-3405 Vincenzo SortinoPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.ORCID 0000-0002-0188-8430 Giovanna VitalitiPediatrics and Pediatric Emergency Operative Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.ORCID 0000-0003-4181-6287 Carla CiminoNeonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.ORCID 0000-0001-9032-7768 Bruna ScaliaNeonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.
Marco Simone VaccalluzzoDepartment of General Surgery and Medical Surgical Specialties, Section of Orthopaedics, A.O.U. Policlinico Rodolico-San Marco, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-3058-062X Michela SpatuzzaInstitute for Biomedical Research and Innovation (IRIB), National Research Council, 98164 Catania, Italy.ORCID 0000-0003-3386-4932 Grete Francesca PriviteraBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1807-4780 Alfredo PulvirentiBioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Piero PavoneUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU Policlinico "G. Rodolico-San Marco", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5600-9560 Martino RuggieriUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU Policlinico "G. Rodolico-San Marco", University of Catania, 95123 Catania, Italy.
Andrea MarinoUnit of Infectious Disease, Department of Clinical and Experimental Medicine, AOU Garibaldi, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5650-6911 Salvatore AgatiCardiovascular Department, Mediterranean Pediatric Cardiology Center, Bambino Gesù Children's Hospital, 98035 Taormina, Italy.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundExtracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival.
methodsWe performed a Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-conformed retrospective observational study and a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our data were analyzed using R (v.4.2.1). We performed survival analysis, correlation analysis, and Fisher's exact test. The first endpoint was the mortality rate. The second endpoint was to evaluate all factors associated with survival. The third endpoint was focused on complications of ECMO.
resultsOur study included 8 patients treated in our centers and 45 patients from the literature review. Survival was 79%. Positive predictive factors of survival were a length of ECMO of less than 10 days and male neonates, while prematurity and the presence of 2 complications were negative predictive factors.
conclusionsECMO functions as life support, although mortality and morbidity risks are high.
Indexed as
ECMO respiratory failureextracorporeal membrane oxygenation∙neonatallife-support
Identifiers
PMID39767870
PMCPMC11674827
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