Genomic Medicine in the Developing World: Cancer Spectrum, Cumulative Risk and Survival Outcomes for Lynch Syndrome Variant Heterozygotes with Germline Pathogenic Variants in the

Lutricia Ndou, Ramadhani Chambuso, Ursula Algar, Adam Boutall, Paul Goldberg, Raj Ramesar

Abstract read

In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Comparative insight: hereditary colorectal cancer registries in Iran, Singapore, and South Africa.Familial cancer · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lutricia NdouUCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, and Affiliated Hospitals, Cape Town 7704, South Africa.ORCID 0000-0002-7203-7780

Ramadhani ChambusoUCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, and Affiliated Hospitals, Cape Town 7704, South Africa.ORCID 0000-0001-8794-604X

Ursula AlgarThe Colorectal Unit, Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.

Adam BoutallThe Colorectal Unit, Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.

Paul GoldbergThe Colorectal Unit, Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.ORCID 0000-0003-1612-7519

Raj RamesarUCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, and Affiliated Hospitals, Cape Town 7704, South Africa.ORCID 0000-0001-5688-1634

Funding

South African Medical Research Council No Grant number

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

colorectal cancercrude survivalcumulative riskextracolonic cancergenetic variantsLynch syndrome registrypathogenic variantsSouth African founder variant

Identifiers

PMID39767815

DOI10.3390/biomedicines12122906

PMCPMC11672899

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.