Evidence map›Paper›PMID 39767790›Full record

ArticleBiomedicines2024

Discordance Between Triglycerides, Remnant Cholesterol and Systemic Inflammation in Patients with Schizophrenia.

Jeffrey Wang, Maaike Kockx, Gabrielle J Pennings, Tim Lambert, Vincent Chow, Leonard Kritharides

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PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeffrey WangAtherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.ORCID 0009-0008-3169-729X
Maaike KockxAtherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.ORCID 0000-0003-0848-5930
Gabrielle J PenningsAtherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.ORCID 0000-0001-6939-5109
Tim LambertConcord Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown 2050, Australia.
Vincent ChowConcord Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown 2050, Australia.
Leonard KritharidesAtherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.ORCID 0000-0001-5818-8024

Funding

New South Wales Ministry of Health CVD Clinician Scientist Grant LK
6 · The paper itself

Abstract

BACKGROUND/

objectivesHypertriglyceridaemia and systemic inflammation are prevalent in patients with schizophrenia and contribute to an increased risk of cardiovascular disease. Although elevated triglycerides (TGs) and remnant cholesterol are linked to inflammation in the general population and individuals with metabolic syndrome, whether they are associated in patients with schizophrenia remains unclear.

methodsFasting levels of TG, cholesterol (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and remnant cholesterol)), and markers of systemic inflammation including high-sensitivity C-reactive protein (hsCRP), leukocyte counts and their differentials (neutrophils, monocytes and lymphocytes) were determined in 147 patients diagnosed with schizophrenia on long-term antipsychotic regimens and compared with 56 age- and sex-matched healthy controls. Apolipoprotein B and glycosylation of acute phase reactant (GlycA) signatures were assessed by NMR. Circulating cytokine levels were measured by a cytokine/chemokine multiplex assay.

resultsPatients with schizophrenia had markedly elevated TG and remnant cholesterol relative to controls and had evidence of systemic inflammation with increased circulating hsCRP, GlycA, leukocyte, neutrophil counts and neutrophil-to-lymphocyte ratio (NLR). Unexpectedly TG and remnant cholesterol did not correlate with systemic inflammatory markers in patients with schizophrenia, and differences in inflammatory markers between controls and patients persisted after adjusting for the lipid profile. Interleukin (IL)-10 levels were increased in patients with schizophrenia, suggesting an anti-inflammatory signature.

conclusionsThe discordance between TG, remnant cholesterol and systemic inflammation in patients with schizophrenia suggests these are likely independent contributors to cardiovascular risk in this population.

Indexed as

hypertriglyceridaemiaremnant cholesterolschizophreniasystemic inflammation

Identifiers

PMID39767790
PMCPMC11673878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.