ArticleBiomedicines2024
Oral Squamous Cell Carcinoma and What We Lose During Formalin Fixation: An Evaluation of Changes in Macroscopic Resection Margins Utilizing Virtual Three-Dimensional Imaging Techniques with Analysis Based on 947 Measurements.
Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mucosal Margin Shrinkage in Oral Cavity Cancer: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Pooled it
- The impact of histology and molecular biology in refining the prognostic value of surgical margins in head and neck oncology - A narrative review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Digital localization of intraoperative samples enhances margin analysis precision in oral squamous cell carcinoma.Frontiers in medicine · 2025Article
- A novel method for histopathological analysis of oral squamous cell carcinoma: a pilot study using three-dimensional imaging to enhance local control.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundAn adequate OSCC macroscopic resection margin (MRM) is essential for effective treatment. This study analyzed the effects of formalin fixation (FF) on the MRM. MATERIAL AND
methodsA total of 42 patients were enrolled in this study. Tumors from the floor of the mouth (FOM; n = 23), the tongue (TC; n = 10), and the maxilla (MT; n = 9) were studied. A 3D scanner was used to create virtual models, and further analysis was conducted according to the established protocol.
resultsThe most significant shrinkage was observed in the TC (MRM n = 121; Med. = 1.5 mm;
conclusionFormalin fixation (FF) caused the shrinkage of the OSCC MRM, particularly in tongue cancers. Even after proper surgical excision in the postoperative results, the number of normal MRMs was underestimated. This should be considered when interpreting the results of surgical treatment. However, FF had a minimal impact on the overall shrinkage of the tumors themselves.
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