Evidence map›Paper›PMID 39767463›Full record

ArticleInternational journal of environmental research and public health2024

Neuropsychological Effects of the Lockdown Due to the COVID-19 Pandemic on Patients with Alzheimer's Disease and Their Caregivers: The "ACQUA" (Alzheimer-COVID QUArantine Questionnaire) Study.

Alessandro Trebbastoni, Roberta Margiotta, Fabrizia D'Antonio, Sonia Barbetti, Marco Canevelli, Sofia Diana, Antonella Di Vita, Letizia Imbriano, Micaela Sepe Monti, Giuseppina Talarico and 2 more

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Article in International journal of environmental research and public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Alessandro TrebbastoniDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9480-0230
Roberta MargiottaDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0657-342X
Fabrizia D'AntonioDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Sonia BarbettiDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Marco CanevelliDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Sofia DianaDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Antonella Di VitaASReM-Azienda Sanitaria Regionale del Molise, 86100 Campobasso, Italy.
Letizia ImbrianoDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Micaela Sepe MontiDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Giuseppina TalaricoDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3608-087X
Cecilia GuarigliaDepartment of Psychology, Sapienza University of Rome, 00185 Rome, Italy.
Giuseppe BrunoDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6948-7169

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe lockdown due to the COVID-19 pandemic, imposed in many countries in 2021, led to social isolation and the interruption of many activities that were useful in stimulating cognition. The impact of these changes has been particularly severe in older subjects with cognitive impairment.

methodsThe present study aimed to investigate the effects of lockdown on Alzheimer's disease patients (in cognition, behavior, and autonomy) and on their caregivers (in emotions, burden, and quality of life). We created a questionnaire and performed an extensive semi-structured telephone interview with each caregiver. The main outcomes were (1) changes in cognitive and behavioral symptoms and autonomy levels in the patients and (2) effects on caregivers' emotions, burden, and quality of life.

resultsThe lockdown severely impaired patients' cognition and independence and worsened behavioral and psychological symptoms of dementia. These effects contributed to increasing caregivers' burden and stress levels, with a significant perceived deterioration in quality of life among caregivers with higher education levels (

conclusionsThis study might contribute to our understanding of the impact of lockdown on Alzheimer's disease patients and their caregivers, to guide future public health interventions aimed at preventing and/or reducing the consequences of similar extraordinary events in frail subjects.

Indexed as

Alzheimer DiseaseCaregiversCOVID-19Quality of LifeQuarantineAgedAged, 80 and overCognitionFemaleHumansMaleMiddle AgedPandemicsSARS-CoV-2Social IsolationSurveys and QuestionnairesAlzheimer’s diseasecaregiverscognitive impairmentCOVID-19dementialockdownpandemicquarantinequestionnaireSARS-CoV-2

Identifiers

PMID39767463
PMCPMC11675157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.