Evidence map›Paper›PMID 39767317›Full record

ReviewBehavioral sciences (Basel, Switzerland)2024

Neuromodulation Strategies in Lifelong Bipolar Disorder: A Narrative Review.

Laura Bernabei, Beniamino Leone, Daniele Hirsch, Valentina Mentuccia, Alessia Panzera, Francesco Riggio, Loredana Sangiovanni, Valentina Piserchia, Giuseppe Nicolò, Enrico Pompili

Abstract readReview
In one paragraph

Review in Behavioral sciences (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura BernabeiDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.ORCID 0000-0001-6281-5561
Beniamino LeoneDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.
Daniele HirschDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.ORCID 0000-0001-6491-2461
Valentina MentucciaDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.
Alessia PanzeraDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.
Francesco RiggioDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Tivoli, 00019 Rome, Italy.
Loredana SangiovanniDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.
Valentina PiserchiaDepartment of Mental Health and Addiction, Centre of Mental Health-ASL Rome 5, Colleferro, 00034 Rome, Italy.ORCID 0000-0002-3903-7519
Giuseppe NicolòDepartment of Mental Health and Addiction, Psychiatric Service of Diagnosis and Care-ASL Rome 5, Colleferro, 00034 Rome, Italy.
Enrico PompiliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Piazza Aldo Moro, 100165 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder is a debilitating psychiatric condition characterized by recurrent episodes of mania and depression, affecting millions worldwide. While pharmacotherapy remains the cornerstone of treatment, a significant proportion of patients exhibit inadequate response or intolerable side effects to conventional medications. In recent years, neuromodulation techniques have emerged as promising adjunctive or alternative treatments for bipolar disorder. We performed a narrative review, according to the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines, to provide a comprehensive overview of the current literature on neuromodulation interventions in bipolar disorder across the course of lifespan. Specifically, it examines the efficacy, safety, and mechanisms of action of various neuromodulation strategies, including, among others, transcranial magnetic stimulation (TMS), electroconvulsive therapy (ECT), vagus nerve stimulation (VNS), deep brain stimulation (DBS), and it describes the therapeutic experiences across the different ages of illness. Additionally, this review discusses the clinical implications, challenges, and future directions of the integration, in clinical practice, of neuromodulation into the management of bipolar disorder. By synthesizing evidence from different studies, this review aims to inform clinicians, researchers, and stakeholders about the evolving landscape of neuromodulation treatments and their potential role in improving outcomes for individuals with bipolar disorder.

Indexed as

bipolar disorderDBSECTneurofeedbackneuromodulationtDCSTMSVNS

Identifiers

PMID39767317
PMCPMC11674029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.