ArticleDiagnostics (Basel, Switzerland)2024
Opportunistic Screening for Osteoporosis by CT as Compared with DXA.
Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Computed tomography-measured trabecular attenuation at first lumbar vertebra as a surrogate marker of bone mineral density and osteoporosis in patients undergoing hemodialysis.Renal failure · 2026Article
- Vertebral trabecular attenuation serial changes on chest CT after autologous hematopoietic stem cell transplantation.Skeletal radiology · 2026Article
- A combined score based on anterior chest wall CT attenuation to aid recognition of SAPHO syndrome: a training-validation study.Frontiers in medicine · 2026Article
- Changes in scanographic bone mineral density in melanoma patients treated with immunotherapy: a new irAE from real-life data.Scientific reports · 2025Article
- Bone Health for Gynaecologists.Medicina (Kaunas, Lithuania) · 2025Review
- Diagnostic utility of IBEX Bone Health for assessment of osteoporosis from knee radiographs.Frontiers in molecular biosciences · 2025Article
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9 authors.
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Abstract
backgroundOsteoporosis is commonly evaluated using dual-energy X-ray absorptiometry (DXA) for bone mineral density (BMD). Non-contrast computed tomography (CT) scans provide an alternative for opportunistic osteoporosis assessment. This study aimed to evaluate screening thresholds for osteoporosis based on CT attenuation values in Hounsfield units (HU) of L1-L4 vertebrae from CT scans of the abdominal region, compared to DXA assessments of the lumbar spine and hips.
methodsConducted retrospectively over approximately two years, the analysis included 109 patients who had both CT and DXA scans within 12 months, excluding those with metal artifacts affecting the vertebrae. CT attenuation values in the trabecular region of the vertebrae were measured and compared among three groups based on the lowest T-score from DXA.
resultsIn a predominantly female cohort (mean age 66.3 years), the lowest CT attenuation values for L1-L4 vertebrae showed a moderate correlation with the lowest T-score, with a Pearson correlation coefficient of 0.542 (95% CI: 0.388, 0.667). A HU threshold of ≤142 at the L1 vertebra showed 91.9% sensitivity and 48.4% specificity, while a threshold of ≤160 HU showed 97.3% sensitivity and 31.3% specificity for screening osteoporosis.
conclusionsThis study supports the use of non-contrast CT with these HU thresholds as an opportunistic tool for osteoporosis assessment.
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